Comedocarcinoma

Comedocarcinoma
SpecialtyOncology

Comedocarcinoma is a kind of breast cancer that demonstrates comedonecrosis, which is the central necrosis[1] of cancer cells within involved ducts. Comedocarcinomas are usually non-infiltrating and intraductal tumors, characterized as a comedo-type, high-grade ductal carcinoma in situ (DCIS). However, there have been accounts of comedocarcinoma which has then diversified into other cell types and developed into infiltrating (invasive) ductal carcinoma.[2] Recurrence and survival rates differ for invasive breast cancer which has originated as comedocarcinoma compared with other types of cancer cells.[3]

  1. ^ Wellfire Interactive. "Pathology Thread". virginia.edu.
  2. ^ Pervez S, Khan H (September 2007). "Infiltrating ductal carcinoma breast with central necrosis closely mimicking ductal carcinoma in situ (comedo type): a case series". Journal of Medical Case Reports. 1: 83. doi:10.1186/1752-1947-1-83. PMC 2014768. PMID 17825107.
  3. ^ Bonnier P, Body G, Bessenay F, Charpin C, Fétissof F, Beedassy B, et al. (May 1999). "Prognostic factors in ductal carcinoma in situ of the breast: results of a retrospective study of 575 cases. The Association for Research in Oncologic Gynecology". European Journal of Obstetrics, Gynecology, and Reproductive Biology. 84 (1): 27–35. doi:10.1016/s0301-2115(99)00007-x. PMID 10413223.