Protein-coding gene in humans
Complement C1r subcomponent (EC 3.4.21.41 , activated complement C1r , C overbar 1r esterase , C1r protein involved in the complement system of the innate immune system .[ 5] [ 6] [ 7] C1R gene .[ 8]
C1r along with C1q and C1s form the C1 complex , which is the first component of the serum complement system. C1r is an enzyme that activates C1s to its active form, by proteolytic cleavage.
^ a b c ENSG00000288512 GRCh38: Ensembl release 89: ENSG00000159403, ENSG00000288512 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000098470 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Sim RB (1981). "The human complement system serine proteases and their proenzymes". Proteolytic Enzymes, Part C . Methods in Enzymology. Vol. 80 Pt C. pp. 26–42. doi :10.1016/s0076-6879(81)80006-7 . ISBN 9780121819804 PMID 6281620 . ^ Leytus SP, Kurachi K, Sakariassen KS, Davie EW (August 1986). "Nucleotide sequence of the cDNA coding for human complement C1r". Biochemistry . 25 (17): 4855–63. doi :10.1021/bi00365a020 . PMID 3021205 . ^ Müller-Eberhard HJ (1988). "Molecular organization and function of the complement system". Annual Review of Biochemistry . 57 : 321–47. doi :10.1146/annurev.bi.57.070188.001541 . PMID 3052276 . ^ "Entrez Gene: C1R complement component 1, r subcomponent" . 
