Complement component 1s

C1S
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesC1S, EDSPD2, complement C1s
External IDsOMIM: 120580; MGI: 3644269; HomoloGene: 1314; GeneCards: C1S; OMA:C1S - orthologs
EC number3.4.21.42
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001734
NM_201442
NM_001346850

NM_173864

RefSeq (protein)

NP_001333779
NP_001725
NP_958850

NP_776289

Location (UCSC)Chr 12: 6.99 – 7.07 MbChr 6: 124.6 – 124.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system. C1s is part of the C1 complex.[5][6][7][8] In humans, it is encoded by the C1S gene.[9]

C1s cleaves C4 and C2, which eventually leads to the production of the classical pathway C3-convertase.

Classical pathway. (Some labels are in Polish.)
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182326Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079343Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sim RB (1981). "The human complement system serine proteases and their proenzymes". Proteolytic Enzymes, Part C. Methods in Enzymology. Vol. 80 Pt C. pp. 26–42. doi:10.1016/s0076-6879(81)80006-7. ISBN 9780121819804. PMID 6281620.
  6. ^ Mackinnon CM, Carter PE, Smyth SJ, Dunbar B, Fothergill JE (December 1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence". European Journal of Biochemistry. 169 (3): 547–53. doi:10.1111/j.1432-1033.1987.tb13644.x. PMID 3500856.
  7. ^ Müller-Eberhard HJ (1988). "Molecular organization and function of the complement system". Annual Review of Biochemistry. 57: 321–47. doi:10.1146/annurev.bi.57.070188.001541. PMID 3052276.
  8. ^ Skoog MT, Mehdi S, Wiseman JS, Bey P (June 1989). "The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 996 (1–2): 89–94. doi:10.1016/0167-4838(89)90099-x. PMID 2500154.
  9. ^ "Entrez Gene: C1S Complement component 1, s subcomponent".