Protein found in humans
Complement component 1s (EC 3.4.21.42 , C1 esterase activated complement C1s , complement C overbar 1r , C1s protein involved in the complement system . C1s is part of the C1 complex .[ 5] [ 6] [ 7] [ 8] C1S gene .[ 9]
C1s cleaves C4 and C2 , which eventually leads to the production of the classical pathway C3-convertase .
Classical pathway. (Some labels are in Polish.)
^ a b c GRCh38: Ensembl release 89: ENSG00000182326 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079343 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Sim RB (1981). "The human complement system serine proteases and their proenzymes". Proteolytic Enzymes, Part C . Methods in Enzymology. Vol. 80 Pt C. pp. 26–42. doi :10.1016/s0076-6879(81)80006-7 . ISBN 9780121819804 PMID 6281620 . ^ Mackinnon CM, Carter PE, Smyth SJ, Dunbar B, Fothergill JE (December 1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence" . European Journal of Biochemistry . 169 (3): 547–53. doi :10.1111/j.1432-1033.1987.tb13644.x PMID 3500856 . ^ Müller-Eberhard HJ (1988). "Molecular organization and function of the complement system". Annual Review of Biochemistry . 57 : 321–47. doi :10.1146/annurev.bi.57.070188.001541 . PMID 3052276 . ^ Skoog MT, Mehdi S, Wiseman JS, Bey P (June 1989). "The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology . 996 (1–2): 89–94. doi :10.1016/0167-4838(89)90099-x . PMID 2500154 . ^ "Entrez Gene: C1S Complement component 1, s subcomponent" . 
