Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a central role in the complement system of vertebrate animals and contributes to innate immunity. In humans it is encoded on chromosome 19 by a gene called C3.[5][6]
Deficiencies and defects of C3 result in the affected person being immunocompromised and particularly vulnerable to bacterial infections.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000125730 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024164 – Ensembl, May 2017
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- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ de Bruijn MH, Fey GH (Feb 1985). "Human complement component C3: cDNA coding sequence and derived primary structure". Proceedings of the National Academy of Sciences of the United States of America. 82 (3): 708–12. Bibcode:1985PNAS...82..708D. doi:10.1073/pnas.82.3.708. PMC 397115. PMID 2579379.
- ^ "Entrez Gene: C3 complement component 3".