Complement component 6

C6
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3T5O, 4A5W, 4E0S
Identifiers
Aliases	C6, complement C6
External IDs	OMIM: 217050; MGI: 88233; HomoloGene: 47; GeneCards: C6; OMA:C6 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	41,261,438 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	4,844,449 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right ventricle; ; cardiac muscle tissue of right atrium; ; right uterine tube; ; myocardium of left ventricle; ; right auricle; ; body of pancreas; ; bronchial epithelial cell; ; pancreatic ductal cell; ; apex of heart;
	Top expressed in
	left lobe of liver; ; mesenteric lymph nodes; ; right lung lobe; ; left lung; ; left lung lobe; ; white adipose tissue; ; spleen; ; mucosa of small intestine; ; subcutaneous adipose tissue; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular region; extracellular exosome; membrane attack complex;
Biological process	positive regulation of activation of membrane attack complex; immune system process; complement activation; in utero embryonic development; cytolysis; regulation of complement activation; immune response; positive regulation of angiogenesis; complement activation, classical pathway; positive regulation of complement activation; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	729
	12274
	ENSG00000039537
	ENSMUSG00000022181
	P13671
	n/a
	NM_000065; NM_001115131
	NM_016704
	NP_000056; NP_001108603
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Complement component 6 is a protein that in humans is encoded by the C6 gene.^[5]

Complement component 6 is a protein involved in the complement system. It is part of the membrane attack complex which can insert into the cell membrane and cause the cell to lyse.

People with C6 deficiency are prone to bacterial infection.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000039537 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022181 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: complement component 6 C6 complement C6 (Homo sapiens (human)) Gene ID: 729". www.ncbi.nlm.nih.gov. 24 November 2020. Retrieved 9 December 2020.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000039537 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022181 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: complement component 6 C6 complement C6 (Homo sapiens (human)) Gene ID: 729". www.ncbi.nlm.nih.gov. 24 November 2020. Retrieved 9 December 2020.

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