Concentrative nucleoside transporter

Nucleos_tra2_C
Identifiers
SymbolNucleos_tra2_C
PfamPF07662
InterProIPR011657
TCDB2.A.41
OPM superfamily388
OPM protein3tij
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Human concentrative nucleoside transporters include SLC28A1, SLC28A2 and SLC28A3 proteins. SLC28A2 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane.[1] SLC28A1 is a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine. It also transports the anti-viral nucleoside analogues Zidovudine and Zalcitabine.[2]

  1. ^ Che M, Ortiz DF, Arias IM (Jun 1995). "Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter". The Journal of Biological Chemistry. 270 (23): 13596–9. doi:10.1074/jbc.270.23.13596. PMID 7775409.
  2. ^ Huang QQ, Yao SY, Ritzel MW, Paterson AR, Cass CE, Young JD (Jul 1994). "Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein". The Journal of Biological Chemistry. 269 (27): 17757–60. doi:10.1016/S0021-9258(17)32370-0. PMID 8027026.