| Conidiobolomycosis | |
|---|---|
| Other names | Rhinoentomophthoromycosis[1] |
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| Conidiobolus coronatus[2] | |
| Specialty | Infectious disease[3] |
| Symptoms | Firm painless swelling in nose, sinuses, cheeks and upper lips, blocked nose, runny nose, nose bleed[4] |
| Complications |
|
| Usual onset | Slowly progressive[6] |
| Duration | Long term[4] |
| Causes | fungi of the genus Conidiobolus[4] |
| Diagnostic method | Medical imaging, biopsy, microscopy, culture[5] |
| Differential diagnosis | Soft tissue tumors,[4] Mucormycosis |
| Treatment | Antifungals, surgical debridement[6] |
| Medication | oral Itraconazole, topical Potassium iodide[6] Severe disease: intravenous Amphotericin B[5] |
| Prognosis | Longterm morbidity: facial disfigurement,[4] good response to treatment[7] |
| Frequency | Rare, M>F[4] adults>children[5] |
| Deaths | Rare[6] |
Conidiobolomycosis is a rare long-term fungal infection that is typically found just under the skin of the nose, sinuses, cheeks and upper lips.[3][4] It may present with a nose bleed or a blocked or runny nose.[4] Typically there is a firm painless swelling which can slowly extend to the nasal bridge and eyes, sometimes causing facial disfigurement.[6]
Most cases are caused by Conidiobolus coronatus, a fungus found in soil and in the environment in general, which can infect healthy people.[4] It is usually acquired by inhaling the spores of the fungus, but can be by direct infection through a cut in the skin such as an insect bite.[3][4]
The extent of disease may be seen using medical imaging such as CT scanning of the nose and sinus.[4] Diagnosis may be confirmed by biopsy, microscopy, culture and histopathology.[4][5] Treatment is with long courses of antifungals and sometimes cutting out infected tissue.[6] The condition has a good response to antifungal treatment,[7] but can recur.[8] The infection is rarely fatal.[6]
The condition occurs more frequently in adults working or living in the tropical forests of South and Central America, West Africa and Southeast Asia.[4][5] Males are affected more than females.[4] The first case in a human was described in Jamaica in 1965.[4]
- ^ Arora P, Sardana K, Madan A, Khurana N (2016). "An Old Woman with a Lump". Indian Journal of Dermatology. 61 (6): 697–699. doi:10.4103/0019-5154.193705. PMC 5122299. PMID 27904202.
- ^ Nie Y, Yu DS, Wang CF, Liu XY, Huang B (24 August 2021). "A taxonomic revision of the genus Conidiobolus (Ancylistaceae, Entomophthorales): four clades including three new genera". MycoKeys (66): 55–81. doi:10.3897/mycokeys.66.46575. PMC 7136305. PMID 32273794.
- ^ a b c "ICD-11 - ICD-11 for Mortality and Morbidity Statistics". icd.who.int. Retrieved 5 June 2021.
- ^ a b c d e f g h i j k l m n o p Chander J (2018). Textbook of Medical Mycology (4th ed.). New Delhi: Jaypee Brothers Medical Publishers Ltd. pp. 599–603. ISBN 978-93-86261-83-0.
- ^ a b c d e f Queiroz-Telles F, Fahal AH, Falci DR, Caceres DH, Chiller T, Pasqualotto AC (November 2017). "Neglected endemic mycoses". The Lancet. Infectious Diseases. 17 (11): e367–e377. doi:10.1016/S1473-3099(17)30306-7. PMID 28774696.
- ^ a b c d e f g Sherchan R, Zahra F (2021). "Entomophthoromycosis". StatPearls. StatPearls Publishing. PMID 34033391.
- ^ a b Gupta N, Sonej M (March 2019). "JCDR – Conidiobolus coronatus, Conidiobolus incongruus, Entomophthoramycosis". Journal of Clinical and Diagnostic Research. 13 (3). doi:10.7860/JCDR/2019/40142.12701.
- ^ Cite error: The named reference
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