 | This article is missing information about genetic and architectural classification (ConoServer and PMC4278219). (April 2019) |
| Alpha conotoxin precursor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 α-Conotoxin PnIB from C. pennaceus, disulfide bonds shown in yellow. From the University of Michigan's Orientations of Proteins in Membranes database, PDB: 1AKG. | |||||||||
| Identifiers | |||||||||
| Symbol | Toxin_8 | ||||||||
| Pfam | PF07365 | ||||||||
| InterPro | IPR009958 | ||||||||
| PROSITE | PDOC60004 | ||||||||
| SCOP2 | 1mii / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 148 | ||||||||
| OPM protein | 1akg | ||||||||
| |||||||||
| Omega conotoxin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Schematic diagram of the three-dimensional structure of ω-conotoxin MVIIA (ziconotide). Disulfide bonds are shown in gold. From PDB: 1DW5. | |||||||||
| Identifiers | |||||||||
| Symbol | Conotoxin | ||||||||
| Pfam | PF02950 | ||||||||
| InterPro | IPR004214 | ||||||||
| SCOP2 | 2cco / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 112 | ||||||||
| OPM protein | 1fyg | ||||||||
| |||||||||
A conotoxin is one of a group of neurotoxic peptides isolated from the venom of the marine cone snail, genus Conus.
Conotoxins, which are peptides consisting of 10 to 30 amino acid residues, typically have one or more disulfide bonds. Conotoxins have a variety of mechanisms of actions, most of which have not been determined. However, it appears that many of these peptides modulate the activity of ion channels.[1] Over the last few decades conotoxins have been the subject of pharmacological interest.[2]
The LD50 of conotoxin ranges from 5-25 μg/kg.[3][4][5]
- ^ Terlau H, Olivera BM (2004). "Conus venoms: a rich source of novel ion channel-targeted peptides". Physiol. Rev. 84 (1): 41–68. doi:10.1152/physrev.00020.2003. PMID 14715910.
- ^ Olivera BM, Teichert RW (2007). "Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery". Molecular Interventions. 7 (5): 251–60. doi:10.1124/mi.7.5.7. PMID 17932414.
- ^ "Archived copy" (PDF). Archived (PDF) from the original on 2017-08-29. Retrieved 2017-03-31.
{{cite web}}: CS1 maint: archived copy as title (link) - ^ "Biological Agent Reference Sheet - Conotoxin" (PDF). Emory University.
- ^ Baker, A.L. "toxin ld50 list". PhycoKey.