| Constance Manuel of Villena | |
|---|---|
 Effigy of Constance Manuel in a 1645 Genealogy of the Kings of Portugal (National Library of Portugal) | |
| Queen consort of Castile and León | |
| Tenure | 1325–1327 |
| Born | c. 1318 Castillo de Garcimuñoz |
| Died | 27 January 1349 Santarém, Portugal |
| Burial | Santarém, Portugal |
| Spouses | Alfonso XI of Castile Peter I of Portugal |
| Issue Among others | Maria, Marchioness of Tortosa Ferdinand I, King of Portugal |
| House | Castilian House of Ivrea |
| Father | Juan Manuel, Prince of Villena |
| Mother | Constance of Aragon, Princess of Villena |
Constanza Manuel of Villena (c. 1318 – 27 January 1349), was a Castilian noblewoman who by her two marriages was Queen consort of Castile and León and Infanta of Portugal.