Contact inhibition

In cell biology, contact inhibition refers to two different but closely related phenomena: contact inhibition of locomotion (CIL) and contact inhibition of proliferation (CIP). CIL refers to the avoidance behavior exhibited by fibroblast-like cells when in contact with one another.[1] In most cases, when two cells contact each other, they attempt to alter their locomotion in a different direction to avoid future collision. When collision is unavoidable, a different phenomenon occurs whereby growth of the cells of the culture itself eventually stops in a cell-density dependent manner.[2]

Both types of contact inhibition are well-known properties of normal cells and contribute to the regulation of proper tissue growth, differentiation, and development. Both types of regulation are normally negated and overcome during organogenesis during embryonic development and tissue and wound healing. However, contact inhibition of locomotion and proliferation are both aberrantly absent in cancer cells, and the absence of this regulation contributes to tumorigenesis.[3]

  1. ^ Abercrombie, M. (September 1970). "Contact inhibition in tissue culture". In Vitro. 6 (2): 128–142. doi:10.1007/BF02616114. PMID 4943054. S2CID 11554527.
  2. ^ Stoker, M.G. (1967). "Density dependent inhibition of cell growth in culture". Nature. 215 (5097): 171–172. Bibcode:1967Natur.215..171S. doi:10.1038/215171a0. PMID 6049107. S2CID 4150783.
  3. ^ Hanahan, D.; Weinberg, R. (7 January 2000). "The Hallmarks of Cancer" (PDF). Cell. 100 (1): 57–70. doi:10.1016/s0092-8674(00)81683-9. PMID 10647931. Retrieved 11 November 2016.