| Membrane protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Model of the external structure of the SARS-CoV-2 virion.[1]
● Blue: envelope ● Turquoise: spike glycoprotein (S) ● Red: envelope proteins (E) ● Green: membrane proteins (M) ● Orange: glycans | |||||||||
| Identifiers | |||||||||
| Symbol | CoV_M | ||||||||
| Pfam | PF01635 | ||||||||
| InterPro | IPR002574 | ||||||||
| PROSITE | PS51927 | ||||||||
| |||||||||
The membrane (M) protein (previously called E1, sometimes also matrix protein[2]) is an integral membrane protein that is the most abundant of the four major structural proteins found in coronaviruses.[3][4][5] The M protein organizes the assembly of coronavirus virions through protein-protein interactions with other M protein molecules as well as with the other three structural proteins, the envelope (E), spike (S), and nucleocapsid (N) proteins.[4][6][7][8]
- ^ Solodovnikov, Alexey; Arkhipova, Valeria (2021-07-29). "Достоверно красиво: как мы сделали 3D-модель SARS-CoV-2" [Truly beautiful: how we made the SARS-CoV-2 3D model] (in Russian). N+1. Archived from the original on 2021-07-30. Retrieved 30 July 2021.
- ^ Hu Y, Wen J, Tang L, Zhang H, Zhang X, Li Y, et al. (May 2003). "The M protein of SARS-CoV: basic structural and immunological properties". Genomics, Proteomics & Bioinformatics. 1 (2): 118–130. doi:10.1016/S1672-0229(03)01016-7. PMC 5172243. PMID 15626342.
- ^ Thomas S. The Structure of the Membrane Protein of SARS-CoV-2 Resembles the Sugar Transporter SemiSWEET. Pathog Immun. 2020 Oct 19;5(1):342-363.
- ^ a b Wong NA, Saier MH (January 2021). "The SARS-Coronavirus Infection Cycle: A Survey of Viral Membrane Proteins, Their Functional Interactions and Pathogenesis". International Journal of Molecular Sciences. 22 (3): 1308. doi:10.3390/ijms22031308. PMC 7865831. PMID 33525632.
- ^ Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF, Connelly S, et al. (April 2011). "A structural analysis of M protein in coronavirus assembly and morphology". Journal of Structural Biology. 174 (1): 11–22. doi:10.1016/j.jsb.2010.11.021. PMC 4486061. PMID 21130884.
- ^ Tseng YT, Wang SM, Huang KJ, Lee AI, Chiang CC, Wang CT (April 2010). "Self-assembly of severe acute respiratory syndrome coronavirus membrane protein". The Journal of Biological Chemistry. 285 (17): 12862–12872. doi:10.1074/jbc.M109.030270. PMC 2857088. PMID 20154085.
- ^ Schoeman D, Fielding BC (May 2019). "Coronavirus envelope protein: current knowledge". Virology Journal. 16 (1): 69. doi:10.1186/s12985-019-1182-0. PMC 6537279. PMID 31133031.
- ^ Masters PS (2006). "The molecular biology of coronaviruses". Advances in Virus Research. 66: 193–292. doi:10.1016/S0065-3527(06)66005-3. ISBN 9780120398690. PMC 7112330. PMID 16877062.