Corticotropin-releasing hormone receptor 1

CRHR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4K5Y, 3EHU, 2L27, 3EHS, 3EHT, 4Z9G
Identifiers
Aliases	CRHR1, CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRH-R1h, CRHR, CRHR1L, CRHR1f, corticotropin releasing hormone receptor 1
External IDs	OMIM: 122561; MGI: 88498; HomoloGene: 20920; GeneCards: CRHR1; OMA:CRHR1 - orthologs
Gene location (Mouse) Chr. Chromosome 11 (mouse)[1] Band 11 E1|11 67.77 cM Start 104,023,681 bp[1] End 104,066,349 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary superior frontal gyrus Brodmann area 9 prefrontal cortex temporal lobe amygdala hippocampus proper hypothalamus ganglionic eminence canal of the cervix Top expressed in cerebellar cortex lumbar subsegment of spinal cord pontine nuclei visual cortex primary visual cortex cerebellar vermis lobe of cerebellum superior frontal gyrus barrel cortex cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity protein binding corticotrophin-releasing factor receptor activity transmembrane signaling receptor activity peptide hormone binding corticotropin-releasing hormone receptor activity corticotropin-releasing hormone binding G-protein alpha-subunit binding peptide binding protein-containing complex binding Cellular component integral component of membrane endosome membrane intrinsic component of plasma membrane plasma membrane integral component of plasma membrane multivesicular body trans-Golgi network dendrite vesicle soma apical part of cell Biological process corticotropin secretion female pregnancy activation of adenylate cyclase activity regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway cell surface receptor signaling pathway birth immune response cellular response to corticotropin-releasing hormone stimulus regulation of corticosterone secretion negative regulation of voltage-gated calcium channel activity signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway hormone-mediated signaling pathway response to hypoxia adenylate cyclase-modulating G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway memory feeding behavior visual learning hypothalamus development adrenal gland development epithelial cell differentiation negative regulation of epinephrine secretion locomotory exploration behavior response to immobilization stress fear response positive regulation of mast cell degranulation positive regulation of cAMP-mediated signaling behavioral response to cocaine behavioral response to ethanol regulation of synaptic plasticity behavioral response to pain response to electrical stimulus general adaptation syndrome, behavioral process long-term potentiation negative regulation of neuron death negative regulation of feeding behavior Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1394 12921 Ensembl n/a ENSMUSG00000018634 UniProt P34998 P35347 RefSeq (mRNA) NM_001145146 NM_001145147 NM_001145148 NM_004382 NM_001303018 NM_001303020 NM_007762 NM_001313928 NM_001313929 RefSeq (protein) NP_001138618 NP_001138619 NP_001138620 NP_001289947 NP_001289949 NP_004373 NP_001300857 NP_001300858 NP_031788 Location (UCSC) n/a Chr 11: 104.02 – 104.07 Mb PubMed search [2] [3]
Wikidata
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Corticotropin-releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF₁, with the latter (CRF₁) now being the IUPHAR-recommended name.^[4] In humans, CRF₁ is encoded by the CRHR1 gene at region 17q21.31, beside micrototubule-associated protein tau MAPT.^[5][6]