Corticotropin-releasing hormone receptor 2

CRHR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N93, 3N95, 3N96
Identifiers
Aliases	CRHR2, CRF-RB, CRF2, CRFR2, HM-CRF, corticotropin releasing hormone receptor 2
External IDs	OMIM: 602034; MGI: 894312; HomoloGene: 55612; GeneCards: CRHR2; OMA:CRHR2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.3 Start 30,651,942 bp[1] End 30,700,129 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 27.33 cM Start 55,067,034 bp[2] End 55,110,001 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle ganglionic eminence ventricular zone apex of heart anterior pituitary muscle of thigh right frontal lobe left ventricle gonad prefrontal cortex Top expressed in muscle of thigh masseter muscle skeletal muscle tissue soleus muscle lumbar spinal ganglion lip embryo esophagus intercostal muscle extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity protein binding corticotrophin-releasing factor receptor activity transmembrane signaling receptor activity peptide hormone binding corticotropin-releasing hormone receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane axon dendrite axon terminus Biological process adenylate cyclase-modulating G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction cellular response to corticotropin-releasing hormone stimulus G protein-coupled receptor signaling pathway hormone-mediated signaling pathway long-term potentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1395 12922 Ensembl ENSG00000106113 ENSMUSG00000003476 UniProt Q13324 Q60748 RefSeq (mRNA) NM_001202475 NM_001202481 NM_001202482 NM_001202483 NM_001883 NM_001288618 NM_001288619 NM_001288620 NM_009953 RefSeq (protein) NP_001189404 NP_001189410 NP_001189411 NP_001189412 NP_001874 NP_001275547 NP_001275548 NP_001275549 NP_034083 Location (UCSC) Chr 7: 30.65 – 30.7 Mb Chr 6: 55.07 – 55.11 Mb PubMed search [3] [4]
Wikidata
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Corticotropin-releasing hormone receptor 2 (CRHR2) is a protein, also known by the IUPHAR-recommended name CRF₂,^[5] that is encoded by the CRHR2 gene and occurs on the surfaces of some mammalian cells. CRF₂ receptors are type 2 G protein-coupled receptors for corticotropin-releasing hormone (CRH) that are resident in the plasma membranes of hormone-sensitive cells. CRH, a peptide of 41 amino acids synthesized in the hypothalamus, is the principal neuroregulator of the hypothalamic-pituitary-adrenal axis, signaling via guanine nucleotide-binding proteins (G proteins) and downstream effectors such as adenylate cyclase. The CRF₂ receptor is a multi-pass membrane protein with a transmembrane domain composed of seven helices arranged in a V-shape. CRF₂ receptors are activated by two structurally similar peptides, urocortin II, and urocortin III, as well as CRH.^[6]