Coxsackievirus-induced cardiomyopathy

Coxsackievirus-induced cardiomyopathy
SpecialtyCardiology

Coxsackieviruses-induced cardiomyopathy are positive-stranded RNA viruses in picornavirus family and the genus enterovirus, acute enterovirus infections such as Coxsackievirus B3 have been identified as the cause of virally induced acute myocarditis, resulting in dilated cardiomyopathy.[1] Dilated cardiomyopathy in humans can be caused by multiple factors including hereditary defects in the cytoskeletal protein dystrophin in Duchenne muscular dystrophy (DMD) patients). A heart that undergoes dilated cardiomyopathy shows unique enlargement of ventricles, and thinning of the ventricular wall that may lead to heart failure. In addition to the genetic defects in dystrophin or other cytoskeletal proteins, a subset of dilated cardiomyopathy is linked to enteroviral infection in the heart, especially coxsackievirus B. Enterovirus infections are responsible for about 30% of the cases of acquired dilated cardiomyopathy in humans.[2]

  1. ^ Badorff, C; Lee, G. H.; Knowlton, K. U. (2000). "Enteroviral cardiomyopathy: bad news for the dystrophin-glycoprotein complex". Herz. 25 (3): 227–32. doi:10.1007/s000590050011. PMID 10904843. S2CID 25973717.
  2. ^ Badorff, C; Lee, G. H.; Lamphear, B. J.; Martone, M. E.; Campbell, K. P.; Rhoads, R. E.; Knowlton, K. U. (1999). "Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy". Nature Medicine. 5 (3): 320–6. doi:10.1038/6543. PMID 10086389. S2CID 9309488.