Coxsackievirus and adenovirus receptor

CXADR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EAJ, 1F5W, 1JEW, 1KAC, 1P69, 1P6A, 1RSF, 2J12, 2J1K, 2NPL, 2W9L, 2WBW, 3J6L, 3J6M, 3J6N, 3J6O
Identifiers
Aliases	CXADR, CAR, CAR4/6, HCAR, coxsackie virus and adenovirus receptor, Ig-like cell adhesion molecule, CXADR Ig-like cell adhesion molecule
External IDs	OMIM: 602621; MGI: 1201679; HomoloGene: 1024; GeneCards: CXADR; OMA:CXADR - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.1 Start 17,513,043 bp[1] End 17,593,579 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.1 Start 78,098,377 bp[2] End 78,156,662 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple palpebral conjunctiva skin of arm skin of thigh vulva pylorus skin of hip jejunal mucosa human penis gums Top expressed in vestibular sensory epithelium ganglionic eminence epithelium of stomach left colon medial ganglionic eminence vestibular membrane of cochlear duct parotid gland left lung lobe atrioventricular valve skin of external ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding beta-catenin binding connexin binding virus receptor activity integrin binding protein binding identical protein binding signaling receptor binding cell adhesion molecule binding cell adhesive protein binding involved in AV node cell-bundle of His cell communication Cellular component cytoplasm integral component of membrane cell body membrane intercalated disc cell-cell junction bicellular tight junction filopodium growth cone adherens junction neuromuscular junction plasma membrane integral component of plasma membrane nucleoplasm extracellular region cell junction apicolateral plasma membrane basolateral plasma membrane acrosomal vesicle membrane raft neuron projection extracellular space protein-containing complex Biological process actin cytoskeleton reorganization heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell junction organization epithelial structure maintenance AV node cell to bundle of His cell communication gamma-delta T cell activation mitochondrion organization neutrophil chemotaxis transepithelial transport homotypic cell-cell adhesion heart development cell adhesion defense response to virus regulation of immune response viral entry into host cell viral process leukocyte migration germ cell migration AV node cell-bundle of His cell adhesion involved in cell communication regulation of AV node cell action potential negative regulation of cardiac muscle cell proliferation cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1525 13052 Ensembl ENSG00000154639 ENSMUSG00000022865 UniProt P78310 P97792 RefSeq (mRNA) NM_001207063 NM_001207064 NM_001207065 NM_001207066 NM_001338 NM_001025192 NM_001276263 NM_009988 RefSeq (protein) NP_001193992 NP_001193993 NP_001193994 NP_001193995 NP_001329 NP_001020363 NP_001263192 NP_034118 Location (UCSC) Chr 21: 17.51 – 17.59 Mb Chr 16: 78.1 – 78.16 Mb PubMed search [3] [4]
Wikidata
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Coxsackievirus and adenovirus receptor (CAR) is a protein that in humans is encoded by the CXADR gene.^[5][6][7] The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. CAR protein is expressed in several tissues, including heart, brain, and, more generally, epithelial and endothelial cells. In cardiac muscle, CAR is localized to intercalated disc structures, which electrically and mechanically couple adjacent cardiomyocytes. CAR plays an important role in the pathogenesis of myocarditis, dilated cardiomyopathy, and in arrhythmia susceptibility following myocardial infarction or myocardial ischemia. In addition, an isoform of CAR (CAR-SIV) has been recently identified in the cytoplasm of pancreatic beta cells. It's been suggested that CAR-SIV resides in the insulin secreting granules and might be involved in the virus infection of these cells.^[8]