Crisaborole

Crisaborole
Clinical data
Pronunciation/juːˈkrɪsə/ yoo-KRIS-ə
Trade namesEucrisa, Staquis
Other namesAN-2728
AHFS/Drugs.comMonograph
MedlinePlusa617019
License data
Pregnancy
category
  • AU: B1
Routes of
administration		Topical (ointment)
ATC code
Legal status
Legal status
  • CA: ℞-only
  • US: ℞-only
  • EU: authorization withdrawn on request of pharmaceutical company
  • In general: ℞ (Prescription only)
Identifiers
  • 4-[(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.225.309 Edit this at Wikidata
Chemical and physical data
FormulaC14H10BNO3
Molar mass251.05 g·mol−1
3D model (JSmol)
  • B1(c2ccc(cc2CO1)Oc3ccc(cc3)C#N)O
  • InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
  • Key:USZAGAREISWJDP-UHFFFAOYSA-N

Crisaborole, sold under the brand name Eucrisa among others, is a nonsteroidal topical medication used for the treatment of mild-to-moderate atopic dermatitis (eczema) in adults and children.[1][2][3][4]

The most common side effects are reactions at the application site (including burning or stinging).[3]

Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor, although its specific mechanism of action in atopic dermatitis is not known.[1][2]

  1. ^ a b "FDA Approves Eucrisa for Eczema" (Press release). U.S. Food and Drug Administration (FDA). 14 December 2016. Public Domain This article incorporates text from this source, which is in the public domain.
  2. ^ a b "Eucrisa- crisaborole ointment". DailyMed. 21 April 2020. Retrieved 28 April 2020.
  3. ^ a b Cite error: The named reference Staquis EPAR was invoked but never defined (see the help page).
  4. ^ He Y, Liu J, Wang Y, Kuai W, Liu R, Wu J (6 February 2023). Pimpinelli N (ed.). "Topical Administration of Crisaborole in Mild to Moderate Atopic Dermatitis: A Systematic Review and Meta-Analysis". Dermatologic Therapy. 2023: 1–9. doi:10.1155/2023/1869934. ISSN 1529-8019.