| Crithidia luciliae | |
|---|---|
| |
| Immunofluorescence staining pattern of anti-dsDNA antibodies on C. luciliae substrate. The kinetoplast, located near the flagellum, is stained, indicating the presence of anti-dsDNA antibodies in a person with SLE. | |
Scientific classification 
| |
| Domain: | Eukaryota |
| Phylum: | Euglenozoa |
| Class: | Kinetoplastea |
| Order: | Trypanosomatida |
| Family: | Trypanosomatidae |
| Genus: | Crithidia |
| Species: | C. luciliae
|
| Binomial name | |
| Crithidia luciliae (Strickland) F.G.Wallace & T.B.Clark
| |
Crithidia luciliae is a flagellate parasite that uses the housefly, Musca domestica, as a host.[1][2] As part of the family of Trypanosomatidae, it is characterised by the presence of a kinetoplast, a complex network of interlocking circular double-stranded DNA (dsDNA) molecules. The presence of the kinetoplast makes this organism important in the diagnosis of systemic lupus erythamatosus (SLE). By using C. luciliae as a substrate for immunofluorescence, the organelle can be used to detect anti-dsDNA antibodies, a common feature of the disease.[3][4]
- ^ "Encyclopedia of Life". Retrieved 27 August 2012.
- ^ JENKINS DW (1964). "Pathogens, Parasites and Predators of Medically Important Arthropods. Annotated List and Bibliography". Bull. World Health Organ. 30 (Suppl): SUPPL:1–150. PMC 2554709. PMID 14245244.
- ^ Donelson JE, Gardner MJ, El-Sayed NM (March 1999). "More surprises from Kinetoplastida". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2579–81. Bibcode:1999PNAS...96.2579D. doi:10.1073/pnas.96.6.2579. PMC 33532. PMID 10077550.
- ^ Kavanaugh A, Tomar R, Reveille J, Solomon DH, Homburger HA (January 2000). "Guidelines for clinical use of the antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. American College of Pathologists". Arch. Pathol. Lab. Med. 124 (1): 71–81. doi:10.5858/2000-124-0071-GFCUOT. PMID 10629135.