| Cullin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex | |||||||||
| Identifiers | |||||||||
| Symbol | Cullin | ||||||||
| Pfam | PF00888 | ||||||||
| InterPro | IPR001373 | ||||||||
| PROSITE | PDOC00967 | ||||||||
| SCOP2 | 1ldj / SCOPe / SUPFAM | ||||||||
| |||||||||
| Cullin protein neddylation domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex | |||||||||
| Identifiers | |||||||||
| Symbol | Cullin_Nedd8 | ||||||||
| Pfam | PF10557 | ||||||||
| InterPro | IPR019559 | ||||||||
| |||||||||
Cullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in myriad cellular processes, most notably protein degradation by ubiquitination.[1][2]
The human genome contains eight cullin genes
- CUL1, part of SCF complex
- CUL2, part of ECS complex (Elongin C - CUL2 - SOCS-box)
- CUL3, part of CUL3-BTB complex
- CUL4A
- CUL4B
- CUL5
- CUL7
- CUL9, also known as PARC
There is also a more distant member called ANAPC2 (or APC2), part of the Anaphase-promoting complex.
CUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit ubiquitin complex.
- ^ Bosu, Dimple R.; Kipreos, Edward T. (2008). "Cullin-RING ubiquitin ligases: Global regulation and activation cycles". Cell Division. 3: 7. doi:10.1186/1747-1028-3-7. PMC 2266742. PMID 18282298.
- ^ Bruce, Alberts (2014-11-18). Molecular biology of the cell (Sixth ed.). New York, NY. ISBN 9780815344322. OCLC 887605755.
{{cite book}}: CS1 maint: location missing publisher (link)