Curculin

Curculin-1
A curculin homodimer. From PDB: 2DPF​.
Identifiers
OrganismMolineria latifolia
SymbolCURC_CURLA
PDB2DPF
UniProtP19667
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StructuresSwiss-model
DomainsInterPro
Curculin-2
Identifiers
OrganismMolineria latifolia
SymbolCURC2_CURLA
PDB2D04
UniProtQ6F495
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StructuresSwiss-model
DomainsInterPro

Curculin or neoculin is a sweet protein complex that was discovered and isolated in 1990 from the fruit of Curculigo latifolia (Hypoxidaceae).[1] Like miraculin, curculin exhibits taste-modifying activity; however, unlike miraculin, it also exhibits a sweet taste by itself. After consumption of curculin, water and sour solutions taste sweet.

mRNAs for a related protein complex is found in Curculigo capitulata fruits, though at a much lower level of expression – so low that the product is undetectable by immunoblotting.[2]

  1. ^ Yamashita H, Theerasilp S, Aiuchi T, et al. (September 1990). "Purification and complete amino acid sequence of a new type of sweet protein taste-modifying activity, curculin". The Journal of Biological Chemistry. 265 (26): 15770–5. doi:10.1016/S0021-9258(18)55464-8. PMID 2394746.
  2. ^ Okubo, S; Terauchi, K; Okada, S; Saito, Y; Yamaura, T; Misaka, T; Nakajima, KI; Abe, K; Asakura, T (13 May 2021). "De novo transcriptome analysis and comparative expression profiling of genes associated with the taste-modifying protein neoculin in Curculigo latifolia and Curculigo capitulata fruits". BMC Genomics. 22 (1): 347. doi:10.1186/s12864-021-07674-3. PMC 8120819. PMID 33985426.Background section cites some more recent work on elucidating the mechanism of sweetness and taste modification.