Cyclic nucleotide-gated channel alpha 3

CNGA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3SWY
Identifiers
Aliases	CNGA3, ACHM2, CCNC1, CCNCa, CCNCalpha, CNCG3, CNG3, Cyclic nucleotide-gated channel alpha 3, cyclic nucleotide gated channel alpha 3, cyclic nucleotide gated channel subunit alpha 3
External IDs	OMIM: 600053; MGI: 1341818; HomoloGene: 994; GeneCards: CNGA3; OMA:CNGA3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	98,398,601 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	37,302,465 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; testicle; ; ganglionic eminence; ; islet of Langerhans; ; pituitary gland; ; anterior pituitary; ; muscle layer of sigmoid colon; ; gastric mucosa; ; right uterine tube; ; C1 segment;
	Top expressed in
	neural layer of retina; ; spermatid; ; embryo; ; quadriceps femoris muscle; ; male reproductive system; ; testicle; ; muscle tissue; ; blastocyst; ; anterior segment of eyeball; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	intracellular cGMP-activated cation channel activity; nucleotide binding; cGMP binding; ion channel activity; ligand-gated ion channel activity; voltage-gated potassium channel activity; protein C-terminus binding; intracellular cAMP-activated cation channel activity;
Cellular component	cytoplasm; integral component of membrane; perikaryon; membrane; soma; dendrite; photoreceptor outer segment membrane; transmembrane transporter complex; integral component of plasma membrane; plasma membrane; axon initial segment; glial cell projection;
Biological process	response to stimulus; regulation of membrane potential; cation transport; response to magnesium ion; ion transport; ion transmembrane transport; response to corticosteroid; transmembrane transport; response to cAMP; signal transduction; visual perception; cation transmembrane transport; potassium ion transmembrane transport; inorganic cation import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	1261
	12790
	ENSG00000144191
	ENSMUSG00000026114
	Q16281
	Q9JJZ8
	NM_001079878; NM_001298
	NM_001282010; NM_009918
	NP_001073347; NP_001289
	NP_001268939; NP_034048
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic nucleotide-gated cation channel alpha-3 is a protein that in humans is encoded by the CNGA3 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144191 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026114 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Distler M, Biel M, Flockerzi V, Hofmann F (November 1994). "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells". Neuropharmacology. 33 (11): 1275–82. doi:10.1016/0028-3908(94)90027-2. PMID 7532814. S2CID 35784152.
^ Wissinger B, Müller F, Weyand I, Schuffenhauer S, Thanos S, Kaupp UB, Zrenner E (December 1997). "Cloning, chromosomal localization and functional expression of the gene encoding the alpha-subunit of the cGMP-gated channel in human cone photoreceptors". The European Journal of Neuroscience. 9 (12): 2512–21. doi:10.1111/j.1460-9568.1997.tb01680.x. PMID 9517456. S2CID 2839367.
^ Hofmann F, Biel M, Kaupp UB (December 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
^ "Entrez Gene: CNGA3 cyclic nucleotide gated channel alpha 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144191 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026114 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7532814-5] Distler M, Biel M, Flockerzi V, Hofmann F (November 1994). "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells". Neuropharmacology. 33 (11): 1275–82. doi:10.1016/0028-3908(94)90027-2. PMID 7532814. S2CID 35784152.

[pmid9517456-6] Wissinger B, Müller F, Weyand I, Schuffenhauer S, Thanos S, Kaupp UB, Zrenner E (December 1997). "Cloning, chromosomal localization and functional expression of the gene encoding the alpha-subunit of the cGMP-gated channel in human cone photoreceptors". The European Journal of Neuroscience. 9 (12): 2512–21. doi:10.1111/j.1460-9568.1997.tb01680.x. PMID 9517456. S2CID 2839367.

[pmid16382102-7] Hofmann F, Biel M, Kaupp UB (December 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.

[entrez-8] "Entrez Gene: CNGA3 cyclic nucleotide gated channel alpha 3".

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