Cyclic nucleotide-gated channel alpha 4

CNGA4
Identifiers
Aliases	CNGA4, CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCBETA, OCNCb, Cyclic nucleotide-gated channel alpha 4, cyclic nucleotide gated channel alpha 4, cyclic nucleotide gated channel subunit alpha 4
External IDs	OMIM: 609472; MGI: 2664099; HomoloGene: 13579; GeneCards: CNGA4; OMA:CNGA4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,244,479 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	105,057,949 bp
RNA expression pattern
	Top expressed in
	gonad; ; right uterine tube; ; testicle; ; bronchial epithelial cell; ; olfactory zone of nasal mucosa; ; left testis; ; right testis; ; C1 segment; ; right lung; ; mucosa of paranasal sinus;
	Top expressed in
	olfactory epithelium; ; zygote; ; secondary oocyte; ; granulocyte; ; primary oocyte; ; dentate gyrus of hippocampal formation granule cell; ; spermatid; ; superior frontal gyrus; ; primary visual cortex; ; testicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; cAMP binding; voltage-gated potassium channel activity; ion channel activity; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; cGMP binding;
Cellular component	Golgi-associated vesicle membrane; integral component of membrane; Golgi membrane; membrane; ciliary membrane; integral component of plasma membrane;
Biological process	transmembrane transport; response to stimulus; sensory perception of smell; ion transport; ion transmembrane transport; regulation of membrane potential; potassium ion transmembrane transport; cation transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1262
	233649
	ENSG00000132259
	ENSMUSG00000030897
	Q8IV77
	Q3UW12
	NM_001037329
	NM_001033317
	NP_001032406
	NP_001028489
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic nucleotide-gated cation channel alpha-4 is a protein that in humans is encoded by the CNGA4 gene.^[5]^[6]^[7]

CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001).[supplied by OMIM]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132259 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030897 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bradley J, Frings S, Yau KW, Reed R (Dec 2001). "Nomenclature for Ion channel Subunits". Science. 294 (5549): 2095–6. doi:10.1126/science.294.5549.2095. PMC 2901924. PMID 11764791.
^ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
^ ^a ^b "Entrez Gene: CNGA4 cyclic nucleotide gated channel alpha 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132259 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030897 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11764791-5] Bradley J, Frings S, Yau KW, Reed R (Dec 2001). "Nomenclature for Ion channel Subunits". Science. 294 (5549): 2095–6. doi:10.1126/science.294.5549.2095. PMC 2901924. PMID 11764791.

[pmid16382102-6] Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.

[entrez-7] "Entrez Gene: CNGA4 cyclic nucleotide gated channel alpha 4".

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