Cyclin-dependent kinase 1

CDK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDK1, CDC2, CDC28A, P34CDC2, cyclin-dependent kinase 1, cyclin dependent kinase 1
External IDsOMIM: 116940; MGI: 88351; HomoloGene: 68203; GeneCards: CDK1; OMA:CDK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007659

RefSeq (protein)

NP_001163877
NP_001163878
NP_001307847
NP_001777
NP_203698

NP_031685

Location (UCSC)Chr 10: 60.78 – 60.79 MbChr 10: 69.17 – 69.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation.[5] It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively.[6] With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates (over 75 have been identified in budding yeast); phosphorylation of these proteins leads to cell cycle progression.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170312Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019942Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Morgan, David L. (2007). The cell cycle: principles of control. London: New Science Press. pp. 30–31. ISBN 978-0-19-920610-0.
  6. ^ Nasmyth K (April 1993). "Control of the yeast cell cycle by the Cdc28 protein kinase". Current Opinion in Cell Biology. 5 (2): 166–179. doi:10.1016/0955-0674(93)90099-C. PMID 8507488.
  7. ^ Enserink JM, Kolodner RD (May 2010). "An overview of Cdk1-controlled targets and processes". Cell Division. 5 (11): 11. doi:10.1186/1747-1028-5-11. PMC 2876151. PMID 20465793.