Cyclin-dependent kinase 5

CDK5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H4L, 1UNG, 1UNH, 1UNL, 3O0G, 4AU8
Identifiers
Aliases	CDK5, Cdk5, AW048668, Crk6, LIS7, PSSALRE, cyclin-dependent kinase 5, cyclin dependent kinase 5
External IDs	OMIM: 123831; MGI: 101765; HomoloGene: 3623; GeneCards: CDK5; OMA:CDK5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.1 Start 151,053,815 bp[1] End 151,057,897 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A3|5 11.73 cM Start 24,623,239 bp[2] End 24,628,528 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe prefrontal cortex nucleus accumbens lateral nuclear group of thalamus Brodmann area 9 cingulate gyrus anterior cingulate cortex caudate nucleus amygdala putamen Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex central gray substance of midbrain nucleus of stria terminalis medial dorsal nucleus anterior horn of spinal cord perirhinal cortex entorhinal cortex hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function acetylcholine receptor activator activity kinase activity cytoskeletal protein binding ATP binding protein kinase activity protein serine/threonine kinase activity ErbB-3 class receptor binding transferase activity ephrin receptor binding tau-protein kinase activity protein binding protein kinase binding nucleotide binding p53 binding ErbB-2 class receptor binding cyclin-dependent protein serine/threonine kinase activity microtubule binding tau protein binding Hsp90 protein binding voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels Cellular component postsynaptic membrane membrane synapse cytoskeleton cell projection lamellipodium perikaryon filopodium growth cone neuromuscular junction plasma membrane axon neuronal cell body postsynaptic density cell junction dendrite protein kinase 5 complex presynapse nucleoplasm nucleus cytoplasm cytosol microtubule neuron projection Schaffer collateral - CA1 synapse postsynapse glutamatergic synapse Biological process synaptic transmission, glutamatergic rhythmic process negative regulation of cell cycle oligodendrocyte differentiation synaptic transmission, dopaminergic protein phosphorylation positive regulation of neuron apoptotic process central nervous system neuron development regulation of synaptic vesicle recycling cell cycle regulated exocytosis corpus callosum development cell population proliferation intracellular protein transport neuron projection development regulation of dendritic spine morphogenesis negative regulation of synaptic plasticity cerebellar cortex formation exocytosis response to cocaine apoptotic process regulation of apoptotic process negative regulation of proteolysis behavioral response to cocaine synaptic vesicle exocytosis receptor clustering positive regulation of calcium ion-dependent exocytosis telencephalon development synaptic vesicle endocytosis response to wounding regulation of postsynaptic membrane potential excitatory postsynaptic potential synapse assembly protein autophosphorylation positive regulation of actin cytoskeleton reorganization negative regulation of neuron death chemical synaptic transmission neuron apoptotic process neuron projection morphogenesis associative learning dendrite morphogenesis phosphorylation calcium ion import Schwann cell development neuron migration cerebellum development nervous system development regulation of synaptic plasticity neuron differentiation cerebral cortex development axon extension sensory perception of pain positive regulation of protein binding cell-matrix adhesion peptidyl-threonine phosphorylation negative regulation of transcription, DNA-templated negative regulation of axon extension cortical actin cytoskeleton organization protein localization to synapse positive regulation of protein targeting to membrane positive regulation of protein kinase activity visual learning regulation of cell migration axonogenesis positive regulation of neuron death receptor catabolic process cell division negative regulation of protein ubiquitination positive regulation of signaling receptor activity negative regulation of protein export from nucleus layer formation in cerebral cortex peptidyl-serine phosphorylation nucleocytoplasmic transport cerebellar cortex development forebrain development motor neuron axon guidance cell migration skeletal muscle tissue development hippocampus development regulation of macroautophagy regulation of signal transduction by p53 class mediator serine phosphorylation of STAT protein microtubule cytoskeleton organization positive regulation of protein phosphorylation mitochondrion organization positive regulation of glial cell apoptotic process synaptic vesicle transport regulation of synaptic transmission, glutamatergic synapse pruning positive regulation of presynaptic cytosolic calcium concentration induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration regulation of protein localization to plasma membrane cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1020 12568 Ensembl ENSG00000164885 ENSMUSG00000028969 UniProt Q00535 P49615 RefSeq (mRNA) NM_001164410 NM_004935 NM_007668 RefSeq (protein) NP_001157882 NP_004926 NP_031694 Location (UCSC) Chr 7: 151.05 – 151.06 Mb Chr 5: 24.62 – 24.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cyclin-dependent kinase 5 is a protein, and more specifically an enzyme, that is encoded by the Cdk5 gene. It was discovered 15 years ago, and it is saliently expressed in post-mitotic central nervous system neurons (CNS).

The molecule belongs to the cyclin-dependent kinase family. Kinases are enzymes that catalyze reactions of phosphorylation. This process allows the substrate to gain a phosphate group donated by an organic compound known as ATP.  Phosphorylations are of vital importance during glycolysis, therefore, making kinases an essential part of the cell due to their role in the metabolism, cell signaling, and many other processes.