Cyclin-dependent kinase 7

CDK7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UA2
Identifiers
Aliases	CDK7, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15, CAK, cyclin-dependent kinase 7, cyclin dependent kinase 7
External IDs	OMIM: 601955; MGI: 102956; HomoloGene: 1363; GeneCards: CDK7; OMA:CDK7 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.2 Start 69,234,795 bp[1] End 69,277,430 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D1|13 53.23 cM Start 100,839,139 bp[2] End 100,867,447 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta gonad islet of Langerhans testicle left testis olfactory zone of nasal mucosa right testis stromal cell of endometrium zone of skin skin of leg Top expressed in otic placode primitive streak abdominal wall renal corpuscle calvaria endocardial cushion morula vas deferens yolk sac migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding ATP-dependent activity, acting on DNA transcription coactivator activity protein C-terminus binding protein binding androgen receptor binding RNA polymerase II CTD heptapeptide repeat kinase activity ATP binding kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity Cellular component nucleoplasm perinuclear region of cytoplasm nucleus cytoplasm cyclin-dependent protein kinase activating kinase holoenzyme complex transcription factor TFIIH holo complex transcription factor TFIIK complex Biological process termination of RNA polymerase I transcription androgen receptor signaling pathway regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription, DNA-templated phosphorylation transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription, DNA-templated cellular response to DNA damage stimulus cell division positive regulation of transcription, DNA-templated protein phosphorylation cell cycle transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter cell population proliferation positive regulation of transcription by RNA polymerase II snRNA transcription by RNA polymerase II nucleotide-excision repair, preincision complex assembly DNA repair protein stabilization G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1022 12572 Ensembl ENSG00000134058 ENSG00000277273 ENSMUSG00000069089 UniProt P50613 Q03147 RefSeq (mRNA) NM_001799 NM_001324069 NM_001324070 NM_001324071 NM_001324072 NM_001324074 NM_001324075 NM_001324077 NM_001324078 NM_009874 RefSeq (protein) NP_001310998 NP_001310999 NP_001311000 NP_001311001 NP_001311003 NP_001311004 NP_001311006 NP_001311007 NP_001790 NP_034004 Location (UCSC) Chr 5: 69.23 – 69.28 Mb Chr 13: 100.84 – 100.87 Mb PubMed search [3] [4]
Wikidata
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Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene.^[5]

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression.

This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.^[6]