Cyclin-dependent kinase inhibitor 1C

CDKN1C
Identifiers
Aliases	CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2, cyclin-dependent kinase inhibitor 1C, cyclin dependent kinase inhibitor 1C
External IDs	OMIM: 600856; MGI: 104564; HomoloGene: 133549; GeneCards: CDKN1C; OMA:CDKN1C - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	2,885,775 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	143,014,787 bp
RNA expression pattern
	Top expressed in
	placenta; ; C1 segment; ; right ovary; ; left ovary; ; right adrenal cortex; ; tibial nerve; ; left adrenal cortex; ; left uterine tube; ; subcutaneous adipose tissue; ; human kidney;
	Top expressed in
	human fetus; ; dermis; ; umbilical cord; ; genital tubercle; ; migratory enteric neural crest cell; ; efferent ductule; ; internal carotid artery; ; choroid plexus of fourth ventricle; ; vas deferens; ; renal corpuscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; protein kinase inhibitor activity; protein-containing complex binding;
Cellular component	cytoplasm; nucleus;
Biological process	positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transcription, DNA-templated; regulation of mitotic cell cycle; negative regulation of epithelial cell proliferation; negative regulation of protein serine/threonine kinase activity; cell cycle; negative regulation of transcription, DNA-templated; negative regulation of kinase activity; negative regulation of cyclin-dependent protein kinase activity; negative regulation of phosphorylation; negative regulation of transcription by RNA polymerase II; skeletal system development; kidney development; placenta development; regulation of exit from mitosis; ageing; myeloid cell differentiation; adrenal gland development; multicellular organism growth; neuron maturation; camera-type eye development; negative regulation of cyclin-dependent protein serine/threonine kinase activity; digestive system development; uterus development; embryonic placenta morphogenesis; genetic imprinting; regulation of lens fiber cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1028
	12577
	ENSG00000273707; ENSG00000129757
	ENSMUSG00000037664
	P49918
	P49919
	NM_000076; NM_001122630; NM_001122631; NM_001362474; NM_001362475
	NM_001161624; NM_009876; NM_001354981
	NP_000067; NP_001116102; NP_001116103; NP_001349403; NP_001349404
	NP_001155096; NP_034006; NP_001341910
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene.^[5]

^ ^a ^b ^c ENSG00000129757 GRCh38: Ensembl release 89: ENSG00000273707, ENSG00000129757 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037664 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)".

[refGRCh38Ensembl-1] ENSG00000129757 GRCh38: Ensembl release 89: ENSG00000273707, ENSG00000129757 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037664 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)".

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