Cyclin A2

CCNA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E9H, 1FIN, 1FVV, 1GY3, 1H1P, 1H1Q, 1H1R, 1H1S, 1H24, 1H25, 1H26, 1H27, 1H28, 1JST, 1JSU, 1OGU, 1OI9, 1OIU, 1OIY, 1OKV, 1OKW, 1OL1, 1OL2, 1P5E, 1PKD, 1QMZ, 1URC, 1VYW, 2BKZ, 2BPM, 2C4G, 2C5N, 2C5O, 2C5V, 2C5X, 2C6T, 2CCH, 2CCI, 2CJM, 2I40, 2IW6, 2IW8, 2IW9, 2UUE, 2UZB, 2UZD, 2UZE, 2UZL, 2V22, 2WEV, 2WFY, 2WHB, 2WIH, 2WIP, 2WMA, 2WMB, 2WPA, 2WXV, 2X1N, 3EID, 3EJ1, 3EOC, 3F5X, 4BCK, 4BCM, 4BCN, 4BCP, 4CFM, 4CFN, 4CFU, 4CFV, 4CFW, 4CFX, 4EOI, 4EOJ, 4EOK, 4EOL, 4EOM, 4EON, 4EOO, 4EOP, 4EOQ, 4EOR, 4EOS, 4FX3, 5CYI, 5IF1
Identifiers
Aliases	CCNA2, CCN1, CCNA, cyclin A2
External IDs	OMIM: 123835; MGI: 108069; HomoloGene: 55562; GeneCards: CCNA2; OMA:CCNA2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	121,823,883 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	36,626,299 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; oocyte; ; secondary oocyte; ; ganglionic eminence; ; gonad; ; bone marrow; ; stromal cell of endometrium; ; rectum; ; mucosa of transverse colon; ; trabecular bone;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; genital tubercle; ; tail of embryo; ; Paneth cell; ; somite; ; ventricular zone; ; maxillary prominence; ; mandibular prominence; ; ureter; ; epiblast;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein kinase binding; cyclin-dependent protein kinase activity; protein domain specific binding; protein kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity;
Cellular component	cytoplasm; female pronucleus; male pronucleus; nucleoplasm; nucleus; cyclin-dependent protein kinase holoenzyme complex; cytosol; cyclin A2-CDK2 complex;
Biological process	cochlea development; cellular response to luteinizing hormone stimulus; response to estradiol; response to glucagon; positive regulation of fibroblast proliferation; cellular response to estradiol stimulus; cellular response to organic cyclic compound; cellular response to insulin-like growth factor stimulus; cellular response to platelet-derived growth factor stimulus; cellular response to leptin stimulus; cell division; positive regulation of transcription, DNA-templated; animal organ regeneration; cellular response to nitric oxide; cell cycle; Ras protein signal transduction; viral process; cellular response to hypoxia; cellular response to cocaine; G2/M transition of mitotic cell cycle; protein deubiquitination; cell cycle G1/S phase transition; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; mitotic cell cycle; regulation of DNA replication; regulation of mitotic nuclear division; positive regulation of cell population proliferation; positive regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	890
	12428
	ENSG00000145386
	ENSMUSG00000027715
	P20248
	P51943
	NM_001237
	NM_009828
	NP_001228
	NP_033958
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene.^[5] It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis while cyclin A2 is expressed in the mitotic division of somatic cells.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145386 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027715 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Paterlini P, De Mitri MS, Martin C, Münnich A, Bréchot C (July 1991). "A TaqI polymorphism in the human cyclin A gene". Nucleic Acids Res. 19 (9): 2516. doi:10.1093/nar/19.9.2516. PMC 329485. PMID 1675006.
^ Yam CH, Fung TK, Poon RY (Aug 2002). "Cyclin A in cell cycle control and cancer". Cell. Mol. Life Sci. 59 (8): 1317–1326. doi:10.1007/s00018-002-8510-y. PMC 11337442. PMID 12363035. S2CID 97398.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145386 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027715 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1675006-5] Paterlini P, De Mitri MS, Martin C, Münnich A, Bréchot C (July 1991). "A TaqI polymorphism in the human cyclin A gene". Nucleic Acids Res. 19 (9): 2516. doi:10.1093/nar/19.9.2516. PMC 329485. PMID 1675006.

[pmid12363035-6] Yam CH, Fung TK, Poon RY (Aug 2002). "Cyclin A in cell cycle control and cancer". Cell. Mol. Life Sci. 59 (8): 1317–1326. doi:10.1007/s00018-002-8510-y. PMC 11337442. PMID 12363035. S2CID 97398.

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