Cyclin B1

CCNB1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2B9R, 2JGZ, 4Y72, 5HQ0, 4YC3
Identifiers
Aliases	CCNB1, CCNB, cyclin B1
External IDs	OMIM: 123836; MGI: 3648694; HomoloGene: 68982; GeneCards: CCNB1; OMA:CCNB1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	69,178,245 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	41,756,609 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; gonad; ; ganglionic eminence; ; testicle; ; mucosa of transverse colon; ; stromal cell of endometrium; ; left testis; ; right testis; ; rectum;
	Top expressed in
	morula; ; blastocyst; ; yolk sac; ; secondary oocyte; ; primary oocyte; ; bone marrow; ; white adipose tissue; ; testicle; ; tail of embryo; ; adrenal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone kinase activity; kinase activity; patched binding; protein binding; cyclin-dependent protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase activator activity; ubiquitin-like protein ligase binding; protein kinase binding; protein kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity;
Cellular component	cytoplasm; centrosome; spindle pole; membrane; nucleoplasm; microtubule organizing center; cytoskeleton; nucleus; cytosol; mitochondrial matrix; cyclin B1-CDK1 complex; cyclin-dependent protein kinase holoenzyme complex;
Biological process	negative regulation of protein phosphorylation; response to DDT; regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of mRNA 3'-end processing; tissue regeneration; positive regulation of fibroblast proliferation; cellular response to iron(III) ion; cellular response to organic cyclic compound; response to mechanical stimulus; positive regulation of mitotic cell cycle; in utero embryonic development; negative regulation of gene expression; regulation of cell cycle; cell division; positive regulation of attachment of spindle microtubules to kinetochore; protein phosphorylation; mitotic nuclear membrane disassembly; cellular response to fatty acid; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; G2/M transition of mitotic cell cycle; oocyte maturation; spermatogenesis; cell cycle; mitotic metaphase plate congression; anaphase-promoting complex-dependent catabolic process; regulation of chromosome condensation; digestive tract development; ventricular cardiac muscle cell development; cellular response to hypoxia; response to toxic substance; mitotic spindle organization; mitotic cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of cyclin-dependent protein serine/threonine kinase activity; protein-containing complex assembly; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic nuclear division; positive regulation of cell population proliferation; transcription initiation from RNA polymerase II promoter; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	891
	434175
	ENSG00000134057
	ENSMUSG00000048574
	P14635
	n/a
	NM_031966; NM_001354844; NM_001354845
	XM_036153675
	NP_114172; NP_001341773; NP_001341774
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134057 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048574 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sartor H, Ehlert F, Grzeschik KH, Müller R, Adolph S (Aug 1992). "Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively". Genomics. 13 (3): 911–2. doi:10.1016/0888-7543(92)90190-4. PMID 1386342.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134057 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048574 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1386342-5] Sartor H, Ehlert F, Grzeschik KH, Müller R, Adolph S (Aug 1992). "Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively". Genomics. 13 (3): 911–2. doi:10.1016/0888-7543(92)90190-4. PMID 1386342.

[1]

[2]

[3]

[4]

[5]