| cyclin E1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CCNE1 | ||||||
| Alt. symbols | CCNE | ||||||
| NCBI gene | 898 | ||||||
| HGNC | 1589 | ||||||
| OMIM | 123837 | ||||||
| RefSeq | NM_001238 | ||||||
| UniProt | P24864 | ||||||
| Other data | |||||||
| Locus | Chr. 19 q12 | ||||||
| |||||||
| cyclin E2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CCNE2 | ||||||
| NCBI gene | 9134 | ||||||
| HGNC | 1590 | ||||||
| OMIM | 603775 | ||||||
| RefSeq | NM_057749 | ||||||
| UniProt | O96020 | ||||||
| Other data | |||||||
| Locus | Chr. 8 q22.1 | ||||||
| |||||||
Cyclin E is a member of the cyclin family.
Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase of the cell cycle that determines initiation of DNA duplication. The Cyclin E/CDK2 complex phosphorylates p27Kip1 (an inhibitor of Cyclin D), tagging it for degradation, thus promoting expression of Cyclin A, allowing progression to S phase.
