Cyclooxygenase-1

PTGS1
Identifiers
Aliases	PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS, prostaglandin-endoperoxide synthase 1
External IDs	OMIM: 176805; MGI: 97797; HomoloGene: 743; GeneCards: PTGS1; OMA:PTGS1 - orthologs
EC number	1.14.99.1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	122,395,703 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	36,142,284 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; germinal epithelium; ; monocyte; ; skin of arm; ; skin of thigh; ; muscle layer of sigmoid colon; ; parietal pleura; ; tendon of biceps brachii; ; skin of abdomen; ; urinary bladder;
	Top expressed in
	medullary collecting duct; ; skin of external ear; ; granulocyte; ; left lung lobe; ; right lung lobe; ; tibiofemoral joint; ; transitional epithelium of urinary bladder; ; right lobe of liver; ; conjunctival fornix; ; lip;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; prostaglandin-endoperoxide synthase activity; dioxygenase activity; heme binding; metal ion binding; peroxidase activity;
Cellular component	nucleus; intracellular membrane-bounded organelle; photoreceptor outer segment; organelle membrane; extracellular exosome; membrane; endoplasmic reticulum; cytoplasm; Golgi apparatus; endoplasmic reticulum membrane;
Biological process	prostaglandin biosynthetic process; fatty acid biosynthetic process; response to oxidative stress; regulation of cell population proliferation; prostaglandin metabolic process; regulation of blood pressure; cyclooxygenase pathway; lipid metabolism; inflammatory response; xenobiotic metabolic process; fatty acid metabolic process; cellular oxidant detoxification;
	Sources:Amigo / QuickGO
Orthologs
	5742
	19224
	ENSG00000095303
	ENSMUSG00000047250
	P23219
	P22437
NM_000962; NM_001271164; NM_001271165; NM_001271166; NM_001271367;
	NM_001271368; NM_080591
	NM_008969
NP_000953; NP_001258093; NP_001258094; NP_001258095; NP_001258296;
	NP_001258297; NP_542158
	NP_032995
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclooxygenase 1 (COX-1), also known as prostaglandin-endoperoxide synthase 1 (HUGO PTGS1), is an enzyme that in humans is encoded by the PTGS1 gene.^[5]^[6] In humans it is one of two cyclooxygenases.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000095303 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047250 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yokoyama C, Tanabe T (December 1989). "Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme". Biochemical and Biophysical Research Communications. 165 (2): 888–94. doi:10.1016/S0006-291X(89)80049-X. PMID 2512924.
^ Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA (June 1991). "Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment". FASEB Journal. 5 (9): 2304–12. doi:10.1096/fasebj.5.9.1907252. PMID 1907252. S2CID 46147389.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000095303 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047250 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2512924-5] Yokoyama C, Tanabe T (December 1989). "Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme". Biochemical and Biophysical Research Communications. 165 (2): 888–94. doi:10.1016/S0006-291X(89)80049-X. PMID 2512924.

[pmid1907252-6] Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA (June 1991). "Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment". FASEB Journal. 5 (9): 2304–12. doi:10.1096/fasebj.5.9.1907252. PMID 1907252. S2CID 46147389.

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