Cyclooxygenase-2

PTGS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5F1A, 5F19, 5IKQ, 5IKT, 5IKV, 5IKR
Identifiers
Aliases	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin-endoperoxide synthase 2
External IDs	OMIM: 600262; MGI: 97798; HomoloGene: 31000; GeneCards: PTGS2; OMA:PTGS2 - orthologs
EC number	1.14.99.1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q31.1 Start 186,671,791 bp[1] End 186,680,922 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 G1|1 63.84 cM Start 149,975,782 bp[2] End 149,983,978 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula cartilage tissue mucosa of urinary bladder beta cell periodontal fiber vena cava visceral pleura saphenous vein mucosa of paranasal sinus gallbladder Top expressed in granulocyte decidua gastrula stroma of bone marrow dentate gyrus cumulus cell endothelial cell of lymphatic vessel right lung lobe calvaria subdivision of hippocampus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function arachidonate 15-lipoxygenase activity metal ion binding heme binding enzyme binding oxidoreductase activity protein homodimerization activity dioxygenase activity protein binding peroxidase activity prostaglandin-endoperoxide synthase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen transferase activity Cellular component cytoplasm endoplasmic reticulum lumen membrane caveola neuron projection organelle membrane endoplasmic reticulum intracellular membrane-bounded organelle endoplasmic reticulum membrane protein-containing complex Biological process response to fructose learning response to organic substance lipoxygenase pathway cellular response to mechanical stimulus response to manganese ion angiogenesis cellular response to hypoxia embryo implantation negative regulation of cell population proliferation response to cytokine negative regulation of smooth muscle contraction memory response to oxidative stress maintenance of blood-brain barrier response to lithium ion response to tumor necrosis factor fatty acid biosynthetic process positive regulation of synaptic transmission, glutamatergic positive regulation of vasoconstriction response to organonitrogen compound inflammatory response positive regulation of smooth muscle contraction bone mineralization response to fatty acid response to vitamin D cellular response to UV positive regulation of fever generation cellular response to fluid shear stress positive regulation of synaptic plasticity regulation of blood pressure response to lipopolysaccharide positive regulation of platelet-derived growth factor production regulation of inflammatory response brown fat cell differentiation sensory perception of pain response to radiation prostaglandin biosynthetic process cellular response to ATP ovulation positive regulation of smooth muscle cell proliferation hair cycle response to estradiol positive regulation of cell death positive regulation of cell migration involved in sprouting angiogenesis response to organic cyclic compound lipid metabolism positive regulation of nitric oxide biosynthetic process response to glucocorticoid cyclooxygenase pathway fatty acid metabolic process positive regulation of fibroblast growth factor production decidualization regulation of cell population proliferation positive regulation of cell population proliferation negative regulation of calcium ion transport positive regulation of apoptotic process positive regulation of transforming growth factor beta production positive regulation of vascular endothelial growth factor production positive regulation of brown fat cell differentiation negative regulation of synaptic transmission, dopaminergic cellular oxidant detoxification ageing NAD biosynthesis via nicotinamide riboside salvage pathway cellular response to heat positive regulation of prostaglandin biosynthetic process positive regulation of peptidyl-serine phosphorylation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to non-ionic osmotic stress negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress cellular response to lead ion response to angiotensin prostaglandin metabolic process positive regulation of protein import into nucleus cytokine-mediated signaling pathway long-chain fatty acid biosynthetic process negative regulation of cell cycle regulation of neuroinflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5743 19225 Ensembl ENSG00000073756 ENSMUSG00000032487 UniProt P35354 Q05769 RefSeq (mRNA) NM_000963 NM_011198 RefSeq (protein) NP_000954 NP_035328 Location (UCSC) Chr 1: 186.67 – 186.68 Mb Chr 1: 149.98 – 149.98 Mb PubMed search [3] [4]
Wikidata
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Cyclooxygenase-2 (COX-2), also known as prostaglandin-endoperoxide synthase 2 (HUGO PTGS2), is an enzyme that in humans is encoded by the PTGS2 gene.^[5] In humans it is one of three cyclooxygenases. It is involved in the conversion of arachidonic acid to prostaglandin H₂, an important precursor of prostacyclin, which is expressed in inflammation.