| Cyclotide family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure and sequence of the prototypic cyclotide kalata B1 | |||||||||
| Identifiers | |||||||||
| Symbol | Cyclotide | ||||||||
| Pfam | PF03784 | ||||||||
| InterPro | IPR005535 | ||||||||
| PROSITE | PDOC51052 | ||||||||
| SCOP2 | 1kal / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 112 | ||||||||
| OPM protein | 1nb1 | ||||||||
| |||||||||
In biochemistry, cyclotides are small, disulfide-rich peptides isolated from plants.[1] Typically containing 28-37 amino acids, they are characterized by their head-to-tail cyclised peptide backbone and the interlocking arrangement of their three disulfide bonds. These combined features have been termed the cyclic cystine knot (CCK) motif. To date, over 100 cyclotides have been isolated and characterized from species of the families Rubiaceae, Violaceae, and Cucurbitaceae. Cyclotides have also been identified in agriculturally important families such as the Fabaceae and Poaceae.[2][3][4]
- ^ Craik DJ, Daly NL, Bond T, Waine C (December 1999). "Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif". Journal of Molecular Biology. 294 (5): 1327–36. doi:10.1006/jmbi.1999.3383. PMID 10600388.
- ^ Poth AG, Colgrave ML, Lyons RE, Daly NL, Craik DJ (June 2011). "Discovery of an unusual biosynthetic origin for circular proteins in legumes". Proceedings of the National Academy of Sciences of the United States of America. 108 (25): 10127–32. Bibcode:2011PNAS..10810127P. doi:10.1073/pnas.1103660108. PMC 3121837. PMID 21593408.
- ^ Nguyen GK, Zhang S, Nguyen NT, Nguyen PQ, Chiu MS, Hardjojo A, Tam JP (July 2011). "Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family". The Journal of Biological Chemistry. 286 (27): 24275–87. doi:10.1074/jbc.M111.229922. PMC 3129208. PMID 21596752.
- ^ Nguyen GK, Lian Y, Pang EW, Nguyen PQ, Tran TD, Tam JP (February 2013). "Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants". The Journal of Biological Chemistry. 288 (5): 3370–80. doi:10.1074/jbc.M112.415356. PMC 3561556. PMID 23195955.