Cytochrome c oxidase subunit 2

COX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VRJ
Identifiers
Aliases	COX2, mitochondrially encoded cytochrome c oxidase II, COII, MTCO2, Cytochrome c oxidase subunit II, CO II
External IDs	OMIM: 516040; MGI: 102503; HomoloGene: 5017; GeneCards: COX2; OMA:COX2 - orthologs
Gene location (Human) Chr. Mitochondrial DNA (human)[1] Band n/a Start 7,586 bp[1] End 8,269 bp[1]
Gene location (Mouse) Chr. Mitochondrial DNA (mouse)[2] Band n/a Start 7,013 bp[2] End 7,696 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon putamen caudate nucleus right frontal lobe nucleus accumbens right hemisphere of cerebellum hippocampus proper substantia nigra muscle layer of sigmoid colon hypothalamus Top expressed in ventricular zone dentate gyrus of hippocampal formation granule cell esophagus zone of skin ovary epiblast jejunum right kidney proximal tubule duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding copper ion binding oxidoreductase activity cytochrome-c oxidase activity Cellular component respiratory chain complex IV respirasome integral component of membrane mitochondrion membrane extracellular exosome mitochondrial respiratory chain complex IV mitochondrial inner membrane Biological process electron transport chain response to cold lactation proton transmembrane transport mitochondrial electron transport, cytochrome c to oxygen ATP synthesis coupled electron transport positive regulation of hydrogen peroxide biosynthetic process positive regulation of necrotic cell death positive regulation of ATP biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4513 17709 Ensembl ENSG00000198712 ENSMUSG00000064354 UniProt P00403 P00405 RefSeq (mRNA) n/a n/a RefSeq (protein) n/a NP_904331 Location (UCSC) Chr M: 0.01 – 0.01 Mb Chr M: 0.01 – 0.01 Mb PubMed search [3] [4]
Wikidata
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Cytochrome c oxidase subunit II, transmembrane domain
Bacterial cytochrome c oxidase complex. Subunit II indicated by blue.
Identifiers
Symbol	COX2_TM
Pfam	PF02790
InterPro	IPR011759
PROSITE	PDOC00075
SCOP2	1occ / SCOPe / SUPFAM
TCDB	3.D.4
OPM superfamily	4
OPM protein	1v55
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Cytochrome c oxidase II is a protein in eukaryotes that is encoded by the MT-CO2 gene.^[5] Cytochrome c oxidase subunit II, abbreviated COXII, COX2, COII, or MT-CO2, is the second subunit of cytochrome c oxidase. It is also one of the three mitochondrial DNA (mtDNA) encoded subunits (MT-CO1, MT-CO2, MT-CO3) of respiratory complex IV.