DAX1

NR0B1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RWV
Identifiers
Aliases	NR0B1, AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2, nuclear receptor subfamily 0 group B member 1, Dax1
External IDs	OMIM: 300473; MGI: 1352460; HomoloGene: 403; GeneCards: NR0B1; OMA:NR0B1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp21.2 Start 30,304,206 bp[1] End 30,309,390 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X C1|X 39.67 cM Start 85,235,370 bp[2] End 85,239,553 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland left adrenal gland right adrenal cortex left adrenal cortex gonad testicle right testis left testis islet of Langerhans germinal epithelium Top expressed in embryo seminiferous tubule adrenal cortex embryo ovary spermatocyte blastocyst ventromedial nucleus Gonadal ridge epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding sequence-specific DNA binding protein homodimerization activity RNA binding nuclear receptor activity AF-2 domain binding DNA binding DNA hairpin binding steroid hormone receptor activity protein binding transcription corepressor activity transcription factor binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus membrane polysomal ribosome nucleoplasm microtubule organizing center nuclear speck intracellular membrane-bounded organelle Biological process sex-determination system spermatogenesis negative regulation of DNA-binding transcription factor activity transcription, DNA-templated response to immobilization stress pituitary gland development gonad development Leydig cell differentiation steroid hormone mediated signaling pathway transcription initiation from RNA polymerase II promoter protein localization hypothalamus development negative regulation of cell differentiation male sex determination Sertoli cell differentiation negative regulation of intracellular steroid hormone receptor signaling pathway regulation of transcription, DNA-templated cell differentiation steroid biosynthetic process male gonad development adrenal gland development negative regulation of transcription, DNA-templated intracellular receptor signaling pathway negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 190 11614 Ensembl ENSG00000169297 ENSMUSG00000025056 UniProt P51843 Q61066 RefSeq (mRNA) NM_000475 NM_007430 RefSeq (protein) NP_000466 NP_000466.2 NP_031456 Location (UCSC) Chr X: 30.3 – 30.31 Mb Chr X: 85.24 – 85.24 Mb PubMed search [3] [4]
Wikidata
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DAX1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) is a nuclear receptor protein that in humans is encoded by the NR0B1 gene (nuclear receptor subfamily 0, group B, member 1).^[5][6][7] The NR0B1 gene is located on the short (p) arm of the X chromosome between bands Xp21.3 and Xp21.2, from base pair 30,082,120 to base pair 30,087,136.