DDOST

DDOST
Identifiers
Aliases	DDOST, AGER1, CDG1R, OKSWcl45, OST, OST48, WBP1, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit, GATD6
External IDs	OMIM: 602202; MGI: 1194508; HomoloGene: 3821; GeneCards: DDOST; OMA:DDOST - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	20,661,544 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,039,939 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; stromal cell of endometrium; ; body of pancreas; ; caput epididymis; ; islet of Langerhans; ; rectum; ; smooth muscle tissue; ; placenta; ; beta cell; ; spleen;
	Top expressed in
	parotid gland; ; lacrimal gland; ; seminal vesicula; ; gastrula; ; dermis; ; islet of Langerhans; ; molar; ; stroma of bone marrow; ; vestibular sensory epithelium; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	dolichyl-diphosphooligosaccharide-protein glycotransferase activity; protein binding; oligosaccharyl transferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; oligosaccharyltransferase complex; plasma membrane; azurophil granule membrane; protein-containing complex;
Biological process	response to cytokine; protein N-linked glycosylation via asparagine; protein glycosylation; protein N-linked glycosylation; T cell activation; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	1650
	13200
	ENSG00000244038
	ENSMUSG00000028757
	P39656
	O54734
	NM_005216
	NM_007838
	NP_005207
	NP_031864
	Wikidata
View/Edit Human	View/Edit Mouse

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase 48 kDa subunit is an enzyme that in humans is encoded by the DDOST gene.^[5]^[6]

This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000244038 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028757 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamagata T, Tsuru T, Momoi MY, Suwa K, Nozaki Y, Mukasa T, Ohashi H, Fukushima Y, Momoi T (Jan 1998). "Genome organization of human 48-kDa oligosaccharyltransferase (DDOST)". Genomics. 45 (3): 535–40. doi:10.1006/geno.1997.4966. PMID 9367678.
^ ^a ^b "Entrez Gene: DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000244038 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028757 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9367678-5] Yamagata T, Tsuru T, Momoi MY, Suwa K, Nozaki Y, Mukasa T, Ohashi H, Fukushima Y, Momoi T (Jan 1998). "Genome organization of human 48-kDa oligosaccharyltransferase (DDOST)". Genomics. 45 (3): 535–40. doi:10.1006/geno.1997.4966. PMID 9367678.

[entrez-6] "Entrez Gene: DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase".

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