DEK (gene)

DEK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Q1V, 2JX3
Identifiers
Aliases	DEK, D6S231E, DEK proto-oncogene
External IDs	OMIM: 125264; MGI: 1926209; HomoloGene: 2593; GeneCards: DEK; OMA:DEK - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	18,264,548 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	47,259,677 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; epithelium of nasopharynx; ; ventricular zone; ; tibia; ; ganglionic eminence; ; trabecular bone; ; amniotic fluid; ; germinal epithelium; ; skin of hip; ; jejunal mucosa;
	Top expressed in
	tail of embryo; ; zygote; ; genital tubercle; ; secondary oocyte; ; primary oocyte; ; epiblast; ; bone marrow; ; ventricular zone; ; thymus; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; histone binding; chromatin binding; RNA binding;
Cellular component	nucleoplasm; contractile fiber; nucleus;
Biological process	epigenetic maintenance of chromatin in transcription-competent conformation; viral genome replication; regulation of double-strand break repair via nonhomologous end joining; transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; regulation of double-strand break repair; signal transduction; chromatin remodeling; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	7913
	110052
	ENSG00000124795
	ENSMUSG00000021377
	P35659
	Q7TNV0
	NM_001134709; NM_003472
	NM_025900
	NP_001128181; NP_003463
	NP_080176
	Wikidata
View/Edit Human	View/Edit Mouse

The human DEK gene encodes the DEK protein.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124795 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021377 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G (Apr 1992). "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA". Mol. Cell. Biol. 12 (4): 1687–97. doi:10.1128/mcb.12.4.1687. PMC 369612. PMID 1549122.
^ "Entrez Gene: DEK DEK oncogene (DNA binding)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124795 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021377 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1549122-5] von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G (Apr 1992). "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA". Mol. Cell. Biol. 12 (4): 1687–97. doi:10.1128/mcb.12.4.1687. PMC 369612. PMID 1549122.

[entrez-6] "Entrez Gene: DEK DEK oncogene (DNA binding)".

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