DHPS

DHPS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DHS, 1RLZ, 1ROZ, 1RQD
Identifiers
Aliases	DHPS, deoxyhypusine synthase, DHS, DS, MIG13, NEDSSWI
External IDs	OMIM: 600944; MGI: 2683592; HomoloGene: 1453; GeneCards: DHPS; OMA:DHPS - orthologs
EC number	2.5.1.46
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,681,880 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,801,791 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; ganglionic eminence; ; primary visual cortex; ; pituitary gland; ; anterior pituitary; ; right uterine tube; ; left ovary; ; prostate; ; muscle of thigh; ; prefrontal cortex;
	Top expressed in
	embryo; ; embryo; ; superior frontal gyrus; ; neural layer of retina; ; aortic valve; ; muscle of thigh; ; ascending aorta; ; supraoptic nucleus; ; epiblast; ; morula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein binding; identical protein binding; deoxyhypusine synthase activity;
Cellular component	cytosol; cytoplasm;
Biological process	protein homotetramerization; protein biosynthesis; positive regulation of T cell proliferation; glucose homeostasis; positive regulation of cell population proliferation; spermidine metabolic process; spermidine catabolic process; peptidyl-lysine modification to peptidyl-hypusine;
	Sources:Amigo / QuickGO
Orthologs
	1725
	330817
	ENSG00000095059
	ENSMUSG00000060038
	P49366
	Q3TXU5
NM_001206974; NM_001930; NM_013406; NM_001369691; NM_001369692;
	NM_001369693
	NM_001039514; NM_201408
NP_001193903; NP_001921; NP_037538; NP_001356620; NP_001356621;
	NP_001356622
	NP_001034603
	Wikidata
View/Edit Human	View/Edit Mouse

Deoxyhypusine synthase is an enzyme that in humans is encoded by the DHPS gene.^[5]^[6]

The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A (EIF5A, EIF5A2). In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. This gene consists of nine exons spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000095059 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060038 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Joe YA, Wolff EC, Park MH (Oct 1995). "Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins". J Biol Chem. 270 (38): 22386–92. doi:10.1074/jbc.270.38.22386. PMID 7673224.
^ ^a ^b "Entrez Gene: DHPS deoxyhypusine synthase".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000095059 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060038 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7673224-5] Joe YA, Wolff EC, Park MH (Oct 1995). "Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins". J Biol Chem. 270 (38): 22386–92. doi:10.1074/jbc.270.38.22386. PMID 7673224.

[entrez-6] "Entrez Gene: DHPS deoxyhypusine synthase".

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