DLST

DLST
Identifiers
Aliases	DLST, DLTS, dihydrolipoamide S-succinyltransferase, PGL7, KGD2
External IDs	OMIM: 126063; MGI: 1926170; HomoloGene: 1456; GeneCards: DLST; OMA:DLST - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	74,903,743 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	85,181,619 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right adrenal cortex; ; left ventricle; ; gastrocnemius muscle; ; left adrenal gland; ; left adrenal cortex; ; right auricle; ; secondary oocyte; ; muscle of thigh; ; skin of leg;
	Top expressed in
	right ventricle; ; muscle of thigh; ; digastric muscle; ; myocardium of ventricle; ; thoracic diaphragm; ; brown adipose tissue; ; right kidney; ; soleus muscle; ; cardiac muscles; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; dihydrolipoyllysine-residue succinyltransferase activity; acyltransferase activity; protein binding;
Cellular component	oxoglutarate dehydrogenase complex; membrane; myelin sheath; mitochondrial matrix; mitochondrion; extracellular exosome; nucleus;
Biological process	tricarboxylic acid cycle; lysine catabolic process; generation of precursor metabolites and energy; L-lysine catabolic process to acetyl-CoA via saccharopine; metabolism; cellular nitrogen compound metabolic process; 2-oxoglutarate metabolic process; succinyl-CoA metabolic process; histone succinylation;
	Sources:Amigo / QuickGO
Orthologs
	1743
	78920
	ENSG00000119689
	ENSMUSG00000004789
	P36957
	Q9D2G2
	NM_001244883; NM_001933
	NM_030225
	NP_001231812; NP_001924
	NP_084501
	Wikidata
View/Edit Human	View/Edit Mouse

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial is an enzyme that in humans is encoded by the DLST gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119689 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004789 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ali G, Wasco W, Cai X, Szabo P, Sheu KF, Cooper AJ, Gaston SM, Gusella JF, Tanzi RE, Blass JP (Jul 1994). "Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex". Somat Cell Mol Genet. 20 (2): 99–105. doi:10.1007/BF02290679. PMID 8009371. S2CID 43092605.
^ "Entrez Gene: DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119689 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004789 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8009371-5] Ali G, Wasco W, Cai X, Szabo P, Sheu KF, Cooper AJ, Gaston SM, Gusella JF, Tanzi RE, Blass JP (Jul 1994). "Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex". Somat Cell Mol Genet. 20 (2): 99–105. doi:10.1007/BF02290679. PMID 8009371. S2CID 43092605.

[entrez-6] "Entrez Gene: DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)".

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