DLX1

DLX1
Identifiers
Aliases	DLX1, Dlx, Dlx-1, distal-less homeobox 1
External IDs	OMIM: 600029; MGI: 94901; HomoloGene: 22558; GeneCards: DLX1; OMA:DLX1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	172,089,677 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	71,364,325 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; testicle; ; anterior cingulate cortex; ; endothelial cell; ; ganglionic eminence; ; prefrontal cortex; ; Brodmann area 23; ; dorsolateral prefrontal cortex; ; primary visual cortex; ; Brodmann area 9;
	Top expressed in
	medial ganglionic eminence; ; olfactory bulb; ; nasolacrimal duct; ; Rostral migratory stream; ; otic vesicle; ; otic placode; ; lateral septal nucleus; ; fossa; ; paraventricular nucleus of hypothalamus; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity;
Cellular component	nucleus;
Biological process	negative regulation of neuron apoptotic process; cerebral cortex GABAergic interneuron differentiation; proximal/distal pattern formation; cell differentiation; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; embryonic skeletal system development; multicellular organism development; odontogenesis of dentin-containing tooth; cerebral cortex GABAergic interneuron fate commitment; negative regulation of oligodendrocyte differentiation; forebrain neuron differentiation; hippocampus development; subpallium development; negative regulation of Notch signaling pathway; positive regulation of cell differentiation; negative regulation of photoreceptor cell differentiation; positive regulation of amacrine cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of BMP signaling pathway; positive regulation of transcription by RNA polymerase II; cellular response to transforming growth factor beta stimulus; cellular response to BMP stimulus; negative regulation of cellular response to transforming growth factor beta stimulus; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	1745
	13390
	ENSG00000144355
	ENSMUSG00000041911
	P56177
	Q64317
	NM_001038493; NM_178120
	NM_010053
	NP_001033582; NP_835221
	NP_034183
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein DLX-1 is a protein that in humans is encoded by the DLX1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144355 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041911 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, et al. (Apr 1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A. 91 (6): 2250–4. Bibcode:1994PNAS...91.2250S. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794.
^ "Entrez Gene: DLX1 distal-less homeobox 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144355 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041911 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7907794-5] Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, et al. (Apr 1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A. 91 (6): 2250–4. Bibcode:1994PNAS...91.2250S. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794.

[entrez-6] "Entrez Gene: DLX1 distal-less homeobox 1".

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