DLX5

DLX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DJN, 4RDU
Identifiers
Aliases	DLX5, SHFM1D, AI385752, distal-less homeobox 5, SHFM1
External IDs	OMIM: 600028; MGI: 101926; HomoloGene: 3825; GeneCards: DLX5; OMA:DLX5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.3 Start 97,020,396 bp[1] End 97,024,950 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 A1|6 2.83 cM Start 6,877,805 bp[2] End 6,882,085 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia gonad skin of leg endometrium skin of abdomen testicle Achilles tendon placenta periodontal fiber ganglionic eminence Top expressed in neural plate Neural groove neural fold molar medial ganglionic eminence genital tubercle Apical ectodermal ridge subthalamus surface ectoderm mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding HMG box domain binding DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component cytoplasm nucleus Biological process skeletal system development roof of mouth development regulation of transcription, DNA-templated epithelial cell differentiation axonogenesis ossification positive regulation of epithelial cell proliferation positive regulation of canonical Wnt signaling pathway anatomical structure formation involved in morphogenesis bone morphogenesis head development cellular response to BMP stimulus ear development endochondral ossification transcription by RNA polymerase II BMP signaling pathway olfactory pit development transcription, DNA-templated nervous system development axon guidance positive regulation of transcription, DNA-templated multicellular organism development embryonic limb morphogenesis inner ear morphogenesis osteoblast differentiation cell population proliferation face morphogenesis positive regulation of transcription by RNA polymerase II positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus positive regulation of gene expression olfactory bulb interneuron differentiation interneuron axon guidance regulation of transcription by RNA polymerase II cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1749 13395 Ensembl ENSG00000105880 ENSMUSG00000029755 UniProt P56178 P70396 RefSeq (mRNA) NM_005221 NM_010056 NM_198854 RefSeq (protein) NP_005212 NP_034186 NP_942151 Location (UCSC) Chr 7: 97.02 – 97.02 Mb Chr 6: 6.88 – 6.88 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein DLX-5 is a protein that in humans is encoded by the distal-less homeobox 5 gene, or DLX5 gene.^[5][6] DLX5 is a member of the DLX gene family.