DMRT1

DMRT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YJ0
Identifiers
Aliases	DMRT1, CT154, DMT1, doublesex and mab-3 related transcription factor 1
External IDs	OMIM: 602424; MGI: 1354733; HomoloGene: 9280; GeneCards: DMRT1; OMA:DMRT1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	969,090 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	25,581,693 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; buccal mucosa cell; ; right testis; ; left testis; ; olfactory zone of nasal mucosa; ; germ cell; ; male germ cell; ; placenta; ; thyroid gland;
	Top expressed in
	Gonadal ridge; ; seminiferous tubule; ; epithelium of seminiferous tubule of testis; ; Sertoli cell; ; spermatogonium; ; spermatid; ; morula; ; morula; ; embryo; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; metal ion binding; protein heterodimerization activity; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; protein homodimerization activity; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	cell differentiation; intracellular signal transduction; male gonad development; regulation of transcription, DNA-templated; regulation of nodal signaling pathway; Sertoli cell differentiation; positive regulation of meiosis I; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; male sex determination; negative regulation of meiotic nuclear division; Sertoli cell development; oocyte development; transcription, DNA-templated; multicellular organism development; developmental process involved in reproduction; male germ cell proliferation; male sex differentiation; cell morphogenesis; spermatogenesis; positive regulation of mitotic nuclear division; positive regulation of male gonad development; germ cell migration; positive regulation of transcription by RNA polymerase II; sex differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1761
	50796
	ENSG00000137090
	ENSMUSG00000024837
	Q9Y5R6
	Q9QZ59
	NM_021951; NM_001363767
	NM_015826
	NP_068770; NP_001350696
	NP_056641
	Wikidata
View/Edit Human	View/Edit Mouse

Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137090 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024837 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: DMRT1 doublesex and mab-3 related transcription factor 1".
^ Raymond CS, Shamu CE, Shen MM, Seifert KJ, Hirsch B, Hodgkin J, Zarkower D (February 1998). "Evidence for evolutionary conservation of sex-determining genes". Nature. 391 (6668): 691–5. Bibcode:1998Natur.391..691R. doi:10.1038/35618. PMID 9490411. S2CID 11414843.
^ Raymond CS, Parker ED, Kettlewell JR, Brown LG, Page DC, Kusz K, Jaruzelska J, Reinberg Y, Flejter WL, Bardwell VJ, Hirsch B, Zarkower D (June 1999). "A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators". Hum. Mol. Genet. 8 (6): 989–96. doi:10.1093/hmg/8.6.989. PMID 10332030.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137090 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024837 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: DMRT1 doublesex and mab-3 related transcription factor 1".

[pmid9490411-6] Raymond CS, Shamu CE, Shen MM, Seifert KJ, Hirsch B, Hodgkin J, Zarkower D (February 1998). "Evidence for evolutionary conservation of sex-determining genes". Nature. 391 (6668): 691–5. Bibcode:1998Natur.391..691R. doi:10.1038/35618. PMID 9490411. S2CID 11414843.

[pmid10332030-7] Raymond CS, Parker ED, Kettlewell JR, Brown LG, Page DC, Kusz K, Jaruzelska J, Reinberg Y, Flejter WL, Bardwell VJ, Hirsch B, Zarkower D (June 1999). "A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators". Hum. Mol. Genet. 8 (6): 989–96. doi:10.1093/hmg/8.6.989. PMID 10332030.

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