DNAJB1

DNAJB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HDJ, 2QLD, 3AGX, 3AGY, 3AGZ, 4WB7
Identifiers
Aliases	DNAJB1, HSPF1, Hdj1, Hsp40, RSPH16B, Sis1, DnaJ heat shock protein family (Hsp40) member B1
External IDs	OMIM: 604572; MGI: 1931874; HomoloGene: 55957; GeneCards: DNAJB1; OMA:DNAJB1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,560,391 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	84,339,282 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; mucosa of pharynx; ; left testis; ; ventricular zone; ; right testis; ; trachea; ; buccal mucosa cell; ; epithelium of esophagus; ; vagina; ; cardia;
	Top expressed in
	seminiferous tubule; ; motor neuron; ; utricle; ; primitive streak; ; ascending aorta; ; aortic valve; ; fossa; ; Epithelium of choroid plexus; ; conjunctival fornix; ; spermatid;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; ATPase binding; Hsp70 protein binding; chaperone binding; protein binding; ATPase activator activity; transcription corepressor activity; cadherin binding;
Cellular component	cytosol; nucleolus; extracellular exosome; nucleus; nucleoplasm; cytoplasm; postsynaptic density; neuronal cell body; dendritic spine; sperm head; postsynapse; glutamatergic synapse;
Biological process	regulation of cellular response to heat; response to unfolded protein; positive regulation of ATP-dependent activity; protein folding; chaperone cofactor-dependent protein refolding; negative regulation of inclusion body assembly; negative regulation of transcription from RNA polymerase II promoter in response to stress; negative regulation of transcription by RNA polymerase II; forebrain development;
	Sources:Amigo / QuickGO
Orthologs
	3337
	81489
	ENSG00000132002
	ENSMUSG00000005483
	P25685
	Q9QYJ3
	NM_001313964; NM_001300914; NM_006145
	NM_018808; NM_001308227
	NP_001287843; NP_001300893; NP_006136
	NP_001295156; NP_061278
	Wikidata
View/Edit Human	View/Edit Mouse

DnaJ homolog subfamily B member 1 is a protein that in humans is encoded by the DNAJB1 gene.^[5]^[6]^[7]

A fusion protein of DNAJB1 and PRKACA drives fibrolamellar hepatocellular carcinoma, a type of rare liver cancer.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132002 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005483 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hata M, Okumura K, Seto M, Ohtsuka K (December 1996). "Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2". Genomics. 38 (3): 446–449. doi:10.1006/geno.1996.0653. PMID 8975727.
^ Ohtsuka K (November 1993). "Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ". Biochemical and Biophysical Research Communications. 197 (1): 235–240. doi:10.1006/bbrc.1993.2466. PMID 8250930.
^ "Entrez Gene: DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1".
^ Neumayer C, Ng D, Jiang CS, Qureshi A, Lalazar G, Vaughan R, et al. (January 2023). "Oncogenic Addiction of Fibrolamellar Hepatocellular Carcinoma to the Fusion Kinase DNAJB1-PRKACA". Clinical Cancer Research. 29 (1): 271–278. doi:10.1158/1078-0432.CCR-22-1851. PMC 9811160. PMID 36302174.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132002 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005483 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8975727-5] Hata M, Okumura K, Seto M, Ohtsuka K (December 1996). "Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2". Genomics. 38 (3): 446–449. doi:10.1006/geno.1996.0653. PMID 8975727.

[pmid8250930-6] Ohtsuka K (November 1993). "Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ". Biochemical and Biophysical Research Communications. 197 (1): 235–240. doi:10.1006/bbrc.1993.2466. PMID 8250930.

[entrez-7] "Entrez Gene: DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1".

[8] Neumayer C, Ng D, Jiang CS, Qureshi A, Lalazar G, Vaughan R, et al. (January 2023). "Oncogenic Addiction of Fibrolamellar Hepatocellular Carcinoma to the Fusion Kinase DNAJB1-PRKACA". Clinical Cancer Research. 29 (1): 271–278. doi:10.1158/1078-0432.CCR-22-1851. PMC 9811160. PMID 36302174.

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