DNA damage-inducible transcript 3

DDIT3
Identifiers
Aliases	DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153, DNA damage-inducible transcript 3, DNA damage inducible transcript 3, C/EBPzeta, AltDDIT3
External IDs	OMIM: 126337; MGI: 109247; HomoloGene: 3012; GeneCards: DDIT3; OMA:DDIT3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 57,516,588 bp[1] End 57,521,737 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 127,126,643 bp[2] End 127,132,157 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary left lobe of thyroid gland substantia nigra gastric mucosa hypothalamus right lobe of thyroid gland putamen C1 segment caudate nucleus right lobe of liver Top expressed in granulocyte neural layer of retina calvaria motor neuron supraoptic nucleus islet of Langerhans seminiferous tubule dentate gyrus of hippocampal formation granule cell ankle joint superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding cAMP response element binding protein binding transcription corepressor activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding leucine zipper domain binding protein binding protein heterodimerization activity protein homodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm cytosol late endosome CHOP-C/EBP complex nucleoplasm transcription factor AP-1 complex protein-DNA complex CHOP-ATF4 complex CHOP-ATF3 complex nucleus Biological process apoptotic process release of sequestered calcium ion into cytosol negative regulation of protein kinase B signaling negative regulation of fat cell differentiation negative regulation of myoblast differentiation regulation of transcription, DNA-templated positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress negative regulation of DNA binding mRNA transcription by RNA polymerase II positive regulation of neuron death negative regulation of transcription by RNA polymerase II Wnt signaling pathway cell redox homeostasis response to endoplasmic reticulum stress PERK-mediated unfolded protein response ER overload response cellular response to DNA damage stimulus transcription, DNA-templated positive regulation of transcription, DNA-templated ATF6-mediated unfolded protein response positive regulation of neuron apoptotic process response to unfolded protein intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding positive regulation of interleukin-8 production response to starvation negative regulation of determination of dorsal identity cell cycle regulation of DNA-templated transcription in response to stress negative regulation of transcription, DNA-templated negative regulation of canonical Wnt signaling pathway positive regulation of transcription by RNA polymerase II proteasome-mediated ubiquitin-dependent protein catabolic process blood vessel maturation negative regulation of CREB transcription factor activity endoplasmic reticulum unfolded protein response establishment of protein localization to mitochondrion intrinsic apoptotic signaling pathway in response to nitrosative stress negative regulation of DNA-binding transcription factor activity positive regulation of DNA-binding transcription factor activity protein complex oligomerization negative regulation of cold-induced thermogenesis regulation of autophagy positive regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1649 13198 Ensembl ENSG00000175197 ENSMUSG00000025408 UniProt P35638 P35639 RefSeq (mRNA) NM_001195053 NM_001195054 NM_001195055 NM_001195056 NM_001195057 NM_004083 NM_001290183 NM_007837 RefSeq (protein) NP_001181982 NP_001181983 NP_001181984 NP_001181985 NP_001181986 NP_004074 NP_001277112 NP_031863 Location (UCSC) Chr 12: 57.52 – 57.52 Mb Chr 10: 127.13 – 127.13 Mb PubMed search [3] [4]
Wikidata
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DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene.^[5][6] It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors.^[6] The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis and has an important role in the cell's stress response.^[6]