DNA ligase 4

LIG4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IK9, 2E2W, 3II6, 3VNN, 3W1B, 3W1G, 3W5O, 4HTO, 4HTP
Identifiers
Aliases	LIG4, LIG4S, DNA ligase 4
External IDs	OMIM: 601837; MGI: 1335098; HomoloGene: 1736; GeneCards: LIG4; OMA:LIG4 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	108,218,368 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	10,027,686 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; oocyte; ; secondary oocyte; ; mucosa of paranasal sinus; ; retinal pigment epithelium; ; Brodmann area 23; ; islet of Langerhans; ; jejunal mucosa; ; primary visual cortex; ; lower lobe of lung;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; thymus; ; zygote; ; hand; ; trigeminal ganglion; ; otolith organ; ; epithelium of lens; ; utricle; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; metal ion binding; protein C-terminus binding; protein binding; ATP binding; DNA ligase (ATP) activity; ligase activity; DNA binding; DNA ligase activity;
Cellular component	nucleoplasm; DNA ligase IV complex; nonhomologous end joining complex; condensed chromosome; nucleus; DNA-dependent protein kinase-DNA ligase 4 complex; cytoplasm; cytoplasmic ribonucleoprotein granule;
Biological process	nucleotide-excision repair, DNA gap filling; double-strand break repair via classical nonhomologous end joining; response to ionizing radiation; DNA recombination; lagging strand elongation; DNA biosynthetic process; cellular response to lithium ion; single strand break repair; cellular response to DNA damage stimulus; cell division; DNA replication; positive regulation of chromosome organization; establishment of integrated proviral latency; cell cycle; response to X-ray; positive regulation of neurogenesis; DNA ligation involved in DNA recombination; DNA ligation; DNA ligation involved in DNA repair; somatic stem cell population maintenance; chromosome organization; T cell receptor V(D)J recombination; neuron apoptotic process; isotype switching; T cell differentiation in thymus; central nervous system development; immunoglobulin V(D)J recombination; double-strand break repair via nonhomologous end joining; positive regulation of fibroblast proliferation; in utero embryonic development; cell population proliferation; V(D)J recombination; pro-B cell differentiation; DNA repair; response to gamma radiation; double-strand break repair; negative regulation of neuron apoptotic process; cellular response to ionizing radiation;
	Sources:Amigo / QuickGO
Orthologs
	3981
	319583
	ENSG00000174405
	ENSMUSG00000049717
	P49917
	Q8BTF7
NM_001098268; NM_002312; NM_206937; NM_001330595; NM_001352598;
	NM_001352599; NM_001352600; NM_001352601; NM_001352602; NM_001352603; NM_001352604; NM_001379095
	NM_176953; NM_001377042
NP_001091738; NP_001317524; NP_002303; NP_996820; NP_001339527;
	NP_001339528; NP_001339529; NP_001339530; NP_001339531; NP_001339532; NP_001339533; NP_001366024
	NP_795927; NP_001363971
	Wikidata
View/Edit Human	View/Edit Mouse

DNA ligase 4 also DNA ligase IV, is an enzyme that in humans is encoded by the LIG4 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174405 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049717 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: LIG4 ligase IV, DNA, ATP-dependent".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174405 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049717 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LIG4 ligase IV, DNA, ATP-dependent".

[1]

[2]

[3]

[4]

[5]