DNA polymerase nu

POLN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XVI, 4XVK, 4XVL, 4XVM
Identifiers
Aliases	POLN, POL4P, polymerase (DNA) nu, DNA polymerase nu
External IDs	OMIM: 610887; MGI: 2675617; HomoloGene: 129696; GeneCards: POLN; OMA:POLN - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	2,242,121 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	34,326,792 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; putamen; ; nucleus accumbens; ; right frontal lobe; ; Brodmann area 9; ; testicle; ; anterior cingulate cortex; ; left testis; ; right testis; ; cerebellar hemisphere;
	Top expressed in
	spermatocyte; ; spermatid; ; brown adipose tissue; ; seminiferous tubule; ; lens; ; lumbar subsegment of spinal cord; ; white adipose tissue; ; primary oocyte; ; zygote; ; epithelium of lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotidyltransferase activity; 5'-3' exonuclease activity; protein binding; cyclin binding; DNA-directed DNA polymerase activity; nucleic acid binding;
Cellular component	cytoplasm; nucleolus; nucleoplasm; nucleus;
Biological process	cellular response to DNA damage stimulus; DNA replication; double-strand break repair via homologous recombination; DNA repair; DNA-dependent DNA replication; interstrand cross-link repair; translesion synthesis; nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	353497
	272158
	ENSG00000130997
	ENSMUSG00000045102
	Q7Z5Q5
	Q7TQ07
	NM_181808
	NM_001289803; NM_001289804; NM_181857
	NP_861524
	NP_001276732; NP_001276733; NP_862905
	Wikidata
View/Edit Human	View/Edit Mouse

Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene.^[5] It is a family A DNA polymerase,^[6] considered to be the least effective of the polymerase enzymes.^[7] However, DNA polymerase nu plays an active role in homology repair during cellular responses to crosslinks, fulfilling its role in a complex with helicase.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130997 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045102 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Polymerase (DNA directed) nu".
^ Marini F, Kim N, Schuffert A, Wood RD (August 2003). "POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308". The Journal of Biological Chemistry. 278 (34): 32014–9. doi:10.1074/jbc.M305646200. PMID 12794064.
^ ^a ^b "UniProtKB - Q7Z5Q5 (DPOLN_HUMAN)". Uniprot. Retrieved 5 July 2018.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130997 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045102 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Polymerase (DNA directed) nu".

[6] Marini F, Kim N, Schuffert A, Wood RD (August 2003). "POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308". The Journal of Biological Chemistry. 278 (34): 32014–9. doi:10.1074/jbc.M305646200. PMID 12794064.

[uniprot-7] "UniProtKB - Q7Z5Q5 (DPOLN_HUMAN)". Uniprot. Retrieved 5 July 2018.

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