DNMT1

DNMT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YOC, 3EPZ, 3PTA, 3SWR, 4WXX
Identifiers
Aliases	DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase 1
External IDs	OMIM: 126375; MGI: 94912; HomoloGene: 124071; GeneCards: DNMT1; OMA:DNMT1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,133,342 bp[1] End 10,231,286 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A3|9 7.66 cM Start 20,818,505 bp[2] End 20,871,184 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte sural nerve ventricular zone ganglionic eminence bone marrow cells appendix cerebellar hemisphere right hemisphere of cerebellum Achilles tendon Top expressed in primary oocyte tail of embryo genital tubercle secondary oocyte zygote urethra paramesonephric duct Paneth cell somite tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity DNA binding transferase activity promoter-specific chromatin binding methyl-CpG binding zinc ion binding DNA-methyltransferase activity chromatin binding metal ion binding protein binding RNA binding DNA (cytosine-5-)-methyltransferase activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component pericentric heterochromatin replication fork nucleoplasm heterochromatin nucleus Biological process C-5 methylation of cytosine regulation of transcription, DNA-templated maintenance of DNA methylation positive regulation of DNA methylation-dependent heterochromatin assembly negative regulation of transcription by RNA polymerase II transcription, DNA-templated methylation DNA methylation positive regulation of gene expression negative regulation of gene expression, epigenetic positive regulation of histone H3-K4 methylation regulation of cell population proliferation negative regulation of histone H3-K9 methylation cellular response to amino acid stimulus regulation of gene expression Ras protein signal transduction negative regulation of transcription, DNA-templated DNA methylation on cytosine DNA methylation involved in embryo development chromatin organization DNA methylation on cytosine within a CG sequence negative regulation of gene expression positive regulation of vascular associated smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell apoptotic process negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1786 13433 Ensembl ENSG00000130816 ENSMUSG00000004099 UniProt P26358 P13864 RefSeq (mRNA) NM_001130823 NM_001379 NM_001318730 NM_001318731 NM_001199431 NM_001199432 NM_001199433 NM_010066 NM_001314011 RefSeq (protein) NP_001124295 NP_001305659 NP_001305660 NP_001370 NP_001186360 NP_001186361 NP_001186362 NP_001300940 NP_034196 NP_001391614 Location (UCSC) Chr 19: 10.13 – 10.23 Mb Chr 9: 20.82 – 20.87 Mb PubMed search [3] [4]
Wikidata
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DNA (cytosine-5)-methyltransferase 1 (Dnmt1) is an enzyme that catalyzes the transfer of methyl groups to specific CpG sites in DNA, a process called DNA methylation. In humans, it is encoded by the DNMT1 gene.^[5] Dnmt1 forms part of the family of DNA methyltransferase enzymes, which consists primarily of DNMT1, DNMT3A, and DNMT3B.