DNMT3B

DNMT3B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QKJ, 3FLG, 5CIU
Identifiers
Aliases	DNMT3B, ICF, ICF1, M.HsaIIIB, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase 3 beta, FSHD4
External IDs	OMIM: 602900; MGI: 1261819; HomoloGene: 56000; GeneCards: DNMT3B; OMA:DNMT3B - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	32,809,356 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	153,529,650 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; hair follicle; ; sperm; ; embryo; ; gonad; ; testicle; ; ganglionic eminence; ; body of pancreas; ; ventricular zone; ; corpus epididymis;
	Top expressed in
	epiblast; ; primitive streak; ; embryo; ; pelvic part of vagina; ; paramesonephric duct; ; epithelium of vagina; ; ejaculatory duct; ; tail of embryo; ; abdominal wall; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; DNA binding; transcription corepressor activity; DNA-methyltransferase activity; chromatin binding; metal ion binding; protein binding; DNA (cytosine-5-)-methyltransferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; nucleus;
Biological process	response to ionizing radiation; C-5 methylation of cytosine; response to estradiol; response to hypoxia; cellular response to hyperoxia; negative regulation of transcription by RNA polymerase II; response to activity; cellular response to dexamethasone stimulus; response to vitamin A; DNA methylation; methylation; positive regulation of gene expression; negative regulation of gene expression, epigenetic; positive regulation of histone H3-K4 methylation; positive regulation of neuron differentiation; negative regulation of histone H3-K9 methylation; regulation of gene expression; response to caffeine; response to toxic substance; response to cocaine;
	Sources:Amigo / QuickGO
Orthologs
	1789
	13436
	ENSG00000088305
	ENSMUSG00000027478
	Q9UBC3
	O88509
NM_001207055; NM_001207056; NM_006892; NM_175848; NM_175849;
	NM_175850
NM_001003960; NM_001003961; NM_001003963; NM_001122997; NM_001271744;
	NM_001271745; NM_001271746; NM_001271747; NM_010068
NP_001193984; NP_001193985; NP_008823; NP_787044; NP_787045;
	NP_787046
NP_001003960; NP_001003961; NP_001003963; NP_001116469; NP_001258673;
	NP_001258674; NP_001258675; NP_001258676; NP_034198
	Wikidata
View/Edit Human	View/Edit Mouse

DNA (cytosine-5)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene.^[5] Mutation in this gene are associated with immunodeficiency, centromere instability and facial anomalies syndrome.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000088305 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027478 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Cite error: The named reference Ehrlich_2003 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000088305 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027478 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

[Ehrlich_2003-6] Cite error: The named reference Ehrlich_2003 was invoked but never defined (see the help page).

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