DPP7

DPP7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JYH, 3N0T, 4EBB
Identifiers
Aliases	DPP7, DPP2, DPPII, QPP, dipeptidyl peptidase 7
External IDs	OMIM: 610537; MGI: 1933213; HomoloGene: 22748; GeneCards: DPP7; OMA:DPP7 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,115,177 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,246,371 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right hemisphere of cerebellum; ; right uterine tube; ; granulocyte; ; right lobe of thyroid gland; ; left testis; ; apex of heart; ; right testis; ; left lobe of thyroid gland; ; right frontal lobe;
	Top expressed in
	choroid plexus of fourth ventricle; ; yolk sac; ; right kidney; ; epithelium of small intestine; ; calvaria; ; proximal tubule; ; human kidney; ; decidua; ; Epithelium of choroid plexus; ; iris;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; aminopeptidase activity; serine-type peptidase activity; dipeptidyl-peptidase activity;
Cellular component	cytosol; Golgi apparatus; lysosome; cytoplasmic vesicle; vesicle; intracellular membrane-bounded organelle; extracellular exosome; extracellular region; azurophil granule lumen;
Biological process	neutrophil degranulation; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	29952
	83768
	ENSG00000176978
	ENSMUSG00000026958
	Q9UHL4
	Q9ET22
	NM_013379
	NM_031843
	NP_037511
	NP_114031
	Wikidata
View/Edit Human	View/Edit Mouse

Dipeptidyl-peptidase 2 is an enzyme that in humans is encoded by the DPP7 gene.^[5]^[6]^[7]

The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolyl carboxypeptidase and is active at both acidic and neutral pH.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176978 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026958 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chiravuri M, Schmitz T, Yardley K, Underwood R, Dayal Y, Huber BT (Oct 1999). "A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase". J Immunol. 163 (6): 3092–9. doi:10.4049/jimmunol.163.6.3092. PMID 10477574.
^ Fukasawa KM, Fukasawa K, Higaki K, Shiina N, Ohno M, Ito S, Otogoto J, Ota N (Jan 2001). "Cloning and functional expression of rat kidney dipeptidyl peptidase II". Biochem J. 353 (Pt 2): 283–90. doi:10.1042/0264-6021:3530283. PMC 1221570. PMID 11139392.
^ ^a ^b "Entrez Gene: DPP7 dipeptidyl-peptidase 7".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176978 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026958 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10477574-5] Chiravuri M, Schmitz T, Yardley K, Underwood R, Dayal Y, Huber BT (Oct 1999). "A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase". J Immunol. 163 (6): 3092–9. doi:10.4049/jimmunol.163.6.3092. PMID 10477574.

[pmid11139392-6] Fukasawa KM, Fukasawa K, Higaki K, Shiina N, Ohno M, Ito S, Otogoto J, Ota N (Jan 2001). "Cloning and functional expression of rat kidney dipeptidyl peptidase II". Biochem J. 353 (Pt 2): 283–90. doi:10.1042/0264-6021:3530283. PMC 1221570. PMID 11139392.

[entrez-7] "Entrez Gene: DPP7 dipeptidyl-peptidase 7".

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