DPT vaccine

For other uses, see DPT (disambiguation).
"TDAP" redirects here. For other uses, see TDAP (disambiguation).

DPT vaccine
Global vaccination coverage- diphtheria-tetanus-pertussis (DTP3) immunization[1]
Combination of
Diphtheria vaccineVaccine
Pertussis vaccineVaccine
Tetanus vaccineVaccine
Clinical data
Trade namesAdacel, Boostrix, Revaxis, others
AHFS/Drugs.comUK Drug Information
Routes of
administration		Intramuscular injection
ATC code
  • None
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
  • none
KEGG
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The DPT vaccine or DTP vaccine is a class of combination vaccines to protect against three infectious diseases in humans: diphtheria, pertussis (whooping cough), and tetanus (lockjaw).[7] The vaccine components include diphtheria and tetanus toxoids, and either killed whole cells of the bacterium that causes pertussis or pertussis antigens. The term toxoid refers to vaccines which use an inactivated toxin produced by the pathogen which they are targeted against to generate an immune response. In this way, the toxoid vaccine generates an immune response which is targeted against the toxin which is produced by the pathogen and causes disease, rather than a vaccine which is targeted against the pathogen itself.[8] The whole cells or antigens will be depicted as either "DTwP"[9] or "DTaP", where the lower-case "w" indicates whole-cell inactivated pertussis and the lower-case "a" stands for "acellular".[10] In comparison to alternative vaccine types, such as live attenuated vaccines, the DTP vaccine does not contain any live pathogen, but rather uses inactivated toxoid (and for pertussis, either a dead pathogen or pure antigens) to generate an immune response; therefore, there is not a risk of use in populations that are immune compromised since there is not any known risk of causing the disease itself. As a result, the DTP vaccine is considered a safe vaccine to use in anyone and it generates a much more targeted immune response specific for the pathogen of interest.[11]

In the United States, the DPT (whole-cell) vaccine was administered as part of the childhood vaccines recommended by the Centers for Disease Control and Prevention (CDC) until 1996, when the acellular DTaP vaccine was licensed for use.[12]

Unless otherwise noted, this article uses "DPT" and "DTP" to refer to any combination vaccine that targets diphtheria, tetanus, and pertussis. The whole-cell vaccine is mentioned either as DTwP or as its historical name (DPT/DTP) with parenthetical remarks.
  1. ^ "Global vaccination coverage: Diphtheria-tetanus-pertussis (DTP3) immunization". Our World in Data. Archived from the original on 21 April 2020. Retrieved 5 March 2020.
  2. ^ "standing orders for Administering Diphtheria, Tetanus, and Acellular Pertussis (DTaP)Vaccine to Children YoungerThan Age 7Years" (PDF). immunize.org. Archived (PDF) from the original on 26 February 2024. Retrieved 4 July 2024.
  3. ^ "standing orders for Administering Tdap/Td Vaccine to Children and Teens Age 7 Years and Older" (PDF). immunize.org. Archived (PDF) from the original on 10 June 2024. Retrieved 4 July 2024.
  4. ^ "standing orders for Administering Td/Tdap Vaccine to Adults" (PDF). immunize.org. Archived (PDF) from the original on 26 February 2024. Retrieved 4 July 2024.
  5. ^ "standing orders for Administering Tdap During Pregnancy" (PDF). immunize.org. Archived (PDF) from the original on 19 May 2024. Retrieved 4 July 2024.
  6. ^ "List of nationally authorised medicinal products" (PDF). ema.europa.eu. Retrieved 4 July 2024.
  7. ^ "DTaP (Diphtheria, Tetanus, Pertussis) Vaccine Information Statement". U.S. Centers for Disease Control and Prevention (CDC). 1 April 2020. Archived from the original on 28 December 2019. Retrieved 27 July 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  8. ^ "Vaccine Types". HHS. 26 April 2021. Archived from the original on 16 July 2021. Retrieved 19 September 2022.
  9. ^ Cite error: The named reference iran-choice was invoked but never defined (see the help page).
  10. ^ Liang JL, Tiwari T, Moro P, Messonnier NE, Reingold A, Sawyer M, et al. (April 2018). "Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP)". MMWR. Recommendations and Reports. 67 (2): 1–44. doi:10.15585/mmwr.rr6702a1. PMC 5919600. PMID 29702631. Public Domain This article incorporates text from this source, which is in the public domain.
  11. ^ "Understanding Six Types of Vaccine Technologies". Pfizer. Archived from the original on 20 September 2022. Retrieved 19 September 2022.
  12. ^ "Birth-18 Years Immunization Schedule". U.S. Centers for Disease Control and Prevention (CDC). 2020. Archived from the original on 6 March 2016. Retrieved 30 July 2020.