DR1 (gene)

DR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JFI
Identifiers
Aliases	DR1, NC2, NC2-BETA, NC2B, down-regulator of transcription 1, NCB2
External IDs	OMIM: 601482; MGI: 1100515; HomoloGene: 38809; GeneCards: DR1; OMA:DR1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	93,369,493 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	108,428,392 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; human penis; ; Skeletal muscle tissue of biceps brachii; ; amniotic fluid; ; buccal mucosa cell; ; Skeletal muscle tissue of rectus abdominis; ; skin of thigh; ; tibia; ; body of tongue; ; oral cavity;
	Top expressed in
	spermatocyte; ; Gonadal ridge; ; barrel cortex; ; seminiferous tubule; ; Paneth cell; ; migratory enteric neural crest cell; ; submandibular gland; ; primitive streak; ; atrioventricular valve; ; hair follicle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	TBP-class protein binding; DNA binding; transcription factor binding; protein binding; transcription corepressor activity; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription coactivator activity; RNA polymerase II general transcription initiation factor activity;
Cellular component	nucleus; negative cofactor 2 complex;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; histone H3 acetylation; transcription, DNA-templated; chromatin remodeling; regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; RNA polymerase II preinitiation complex assembly; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1810
	13486
	ENSG00000117505
	ENSMUSG00000029265
	Q01658
	Q91WV0
	NM_001938
	NM_026106
	NP_001929
	NP_080382
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Dr1 is a protein that in humans is encoded by the DR1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117505 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029265 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Inostroza JA, Mermelstein FH, Ha I, Lane WS, Reinberg D (Sep 1992). "Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription". Cell. 70 (3): 477–89. doi:10.1016/0092-8674(92)90172-9. PMID 1339312.
^ Purrello M, Di Pietro C, Rapisarda A, Viola A, Corsaro C, Motta S, Grzeschik KH, Sichel G (1996). "Genomic localization of the human gene encoding Dr1, a negative modulator of transcription of class II and class III genes". Cytogenetics and Cell Genetics. 75 (2–3): 186–9. doi:10.1159/000134479. PMID 9040789.
^ "Entrez Gene: DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117505 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029265 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1339312-5] Inostroza JA, Mermelstein FH, Ha I, Lane WS, Reinberg D (Sep 1992). "Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription". Cell. 70 (3): 477–89. doi:10.1016/0092-8674(92)90172-9. PMID 1339312.

[pmid9040789-6] Purrello M, Di Pietro C, Rapisarda A, Viola A, Corsaro C, Motta S, Grzeschik KH, Sichel G (1996). "Genomic localization of the human gene encoding Dr1, a negative modulator of transcription of class II and class III genes". Cytogenetics and Cell Genetics. 75 (2–3): 186–9. doi:10.1159/000134479. PMID 9040789.

[entrez-7] "Entrez Gene: DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)".

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